Andrew Huberman has repeatedly emphasized that psychedelics interact with neuroplasticity and learning states.

We are aligned with this direction.

→ Heightened plasticity increases the importance of post-experience infrastructure, monitoring, and continuity systems.

#Psychedelics #Neuroscience #MentalHealth #PsychedelicResearch #Neuroplasticity #PublicHealth

#Psychedelic therapy assumed the hallucination was part of the mechanism.

UC Davis researchers created compounds that fully activate the same brain receptor as psychedelics - with zero hallucinogenic effects in animal tests.

Therapeutic benefit and the trip may operate through different pathways.

A rare new molecular scaffold with implications for #depression, PTSD, and addiction treatment.

#Neuroscience #MentalHealth #PsychedelicResearch #Science

https://www.sciencedaily.com/releases/2026/05/260512202325.htm

New psychedelic-like drugs could treat depression without making you trip

UC Davis researchers created brand-new psychedelic-like compounds by shining UV light on amino acid-based molecules. These compounds activated key serotonin receptors tied to brain plasticity and mental health benefits, but surprisingly did not cause hallucination-like behavior in animal tests. Scientists say the discovery could lead to future treatments for depression, PTSD, and addiction without the intense psychedelic experience.

ScienceDaily

The article reports that a single dose of ibogaine in Special Operations veterans with traumatic brain injury and PTSD led to lasting changes in brain blood flow and widespread reorganization of neural networks, with associated symptom improvements. Functional imaging tracked blood flow and network connectivity before, immediately after, and one month after treatment, revealing persistent metabolic changes and network remodeling.

This piece is of interest to psychology readers because it links neurobiological changes to symptom relief and demonstrates how psychedelic-assisted interventions may influence brain network dynamics in trauma-related conditions.

Article Title: Brain scans reveal how ibogaine alters neural networks in veterans with head trauma

Link to PsyPost Article: https://nolinkpreview.com/www.psypost.org/brain-scans-reveal-how-ibogaine-alters-neural-networks-in-veterans-with-head-tra/

#neuroplasticity #ibogaine #traumaticbraininjury #PTSD #functionalneuroimaging #brainnetworks #neuroscience #psychedelicresearch #veteranshealth #cognitivefunction

The article discusses a study comparing psychedelic enthusiasts with a general population sample to examine whether self-reported quality-of-life benefits from psychedelic experiences are inflated by selection bias. It highlights how differences in mindset, setting, motivation, and personality may influence reported outcomes, suggesting caution in interpreting psychedelic research that relies on highly engaged user groups.

The topic is of interest to readers with an interest in psychology because it addresses methodological issues in how experiences and personality traits can shape self-reported psychological outcomes, illustrating the importance of sample sourcing and bias considerations in research interpretation.

Article Title: Are the benefits of psychedelics exaggerated? A new study highlights the problem of selection bias

Link to PsyPost Article: https://nolinkpreview.com/www.psypost.org/are-the-benefits-of-psychedelics-exaggerated-a-new-study-highlights-the-problem-of-selection-bias/

#psychedelics #psychology #researchbias #qualityoflife #selectionbias #methodology #psychedelicresearch #samplebias #personality #mindset

The article reports findings from a study showing that meaningful psychedelic experiences are associated with reduced fear of death and increased feelings of connectedness to self, others, and the world, with the degree of connectedness tracking the amount of fear reduction. It also notes two possible pathways: genuine acceptance through interpersonal and self-connection, and a defensive shift linked to mystical experiences.

This topic is of interest to psychology readers because it highlights how altered states of consciousness can influence existential concerns, relationship to self and others, and meaning-making processes, prompting questions about mechanisms, interpretation, and integration.

Article Title: New study explores the link between mystical psychedelic trips and a reduced fear of dying

Link to PsyPost Article: https://nolinkpreview.com/www.psypost.org/new-study-explores-the-link-between-mystical-psychedelic-trips-and-a-reduced-fear-of-dying/

#psychedelicresearch #deathanxiety #connectedness #mysticalexperiences #psychedelictherapy #deathfear #existentialpsychology #spiritualexperience #psychologynews #mentalhealthresearch

This article reports that a single dose of psilocybin, combined with behavioral counseling, produced higher quit rates for smoking than a standard nicotine patch with the same counseling, in a randomized trial.

The topic is of interest to psychology readers because it explores how psychedelic-assisted approaches may influence behavior change, motivation, and the psychological processes underlying addiction and habit formation.

Article Title: A single dose of psilocybin outperforms nicotine patches for quitting smoking

Link to PsyPost Article: https://nolinkpreview.com/www.psypost.org/a-single-dose-of-psilocybin-outperforms-nicotine-patches-for-quitting-smoking/

#psilocybin #smokingcessation #psychedelicresearch #behavioraltherapy #addictionscience

Spotlight: Psychedelics in Palliative Care, Ready for Primetime! Making the Case for Ketamine-Assisted Psychotherapy (Horowitz, et al, 2024)

"Preliminary evidence demonstrates that Ketamine-Assisted Psychotherapy (KAP) can significantly improve depression, demoralization and existential distress in seriously ill people"

Psychedelic Mental Health Institute
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2847667 #Ketamine and #esketamine can be tested as active placebos and administered in all the ways other psychedelic medicines are. These medicines are FDA approved and have been studied for 60+ years. Compare #psychedelics in a double blind study with ketamine. Wild that this isn’t the common approach in #psychedelicresearch

This article reports that a single dose of psilocybin can lead to lasting shifts in life values, including greater appreciation for life and self-acceptance, with changes linked to acute experiences of unity and euphoria. The findings come from a controlled trial in healthy volunteers and highlight how the psychedelic state may influence personal values over weeks.

This topic is of interest to psychology because it examines how altered states of consciousness can shape core beliefs, self-perception, and prosocial concerns, contributing to discussions about personality, meaning, and well-being.

Article Title: Can a psychedelic journey change what you value most?

Link to PsyPost Article: https://www.psypost dot org/psilocybin-triggers-lasting-changes-in-personal-values-for-healthy-volunteers/

Copy and paste broken link above into your browser and replace "dot" with "." for link to work. We have to do it this way to avoid displaying copyrighted images.

#psychedelics #psychology #personalvalues #psychedelicresearch #wellbeing

Impact of subanesthetic ketamine delivered via AmyloLipid nanovesicle (ALN)-based intranasal system on biobehavioral responses in an animal model of PTSD - PubMed

Ketamine holds promise for the treatment of post-traumatic stress disorder (PTSD), but challenges remain in delivery and sustained effects. This controlled study evaluates a novel intranasal formulation, employing AmyloLipid nanovesicles (ALN) to enhance ketamine's therapeutic efficacy in a predator …

PubMed