Impact of subanesthetic ketamine delivered via AmyloLipid nanovesicle (ALN)-based intranasal system on biobehavioral responses in an animal model of PTSD - PubMed

Ketamine holds promise for the treatment of post-traumatic stress disorder (PTSD), but challenges remain in delivery and sustained effects. This controlled study evaluates a novel intranasal formulation, employing AmyloLipid nanovesicles (ALN) to enhance ketamine's therapeutic efficacy in a predator …

PubMed
https://psychedelicmentalhealth.net/spotlight-n-n-dimethyltryptamine-elicits-antidepressant-and-anxiolytic-effects-in-helpless-mice-a-comparative-study-with-s-ketamine-da-sousa-silva-et-al-2026/ Spotlight: N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine (da Sousa-Silva, et al, 2026)
#DMT compared with #ketamine variant, #esketamine in mice. #depression #anxiety #psychedelics #psychedelic #psychedelicresearch
Spotlight: N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine (da Sousa-Silva, et al, 2026)

DMT compared with ketamine variant, esketamine in mice.

Psychedelic Institute - Psychedelics in Mental Health

#til one if the first #ketamine studies for #mentalhealth was in 1973 out of #iran “The Use of Ketamine in Psychiatry” by
E. Khorramzadeh M.D, A.O. Lotfy M.D.
Assistant Professor, Dept. of Psychiatry, Pahlavi University School of Medicine, Shiraz, Iran
Professor, Dept. of Anesthesiology, Pahlavi University School of Medicine, Shiraz, Iran #psychedelics #ketaminetherapy #psychedelicresearch #nowar

https://www.sciencedirect.com/science/article/pii/S0033318273713062?via%3Dihub

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The article argues that ideological concerns and media sensationalism, rather than scientific evidence of harm, shaped the global prohibition of psychedelics in 1971, with diplomacy and political context playing central roles.

The piece highlights how political and cultural factors influence perceptions of psychology-related substances, making it of particular interest to those studying how societal narratives shape mental health policy and research access.

Article Title: New analysis shows ideology, not science, drove the global prohibition of psychedelics

Link to PsyPost Article: https://www.psypost dot org/new-analysis-shows-ideology-not-science-drove-the-global-prohibition-of-psychedelics/

Copy and paste broken link above into your browser and replace "dot" with "." for link to work. We have to do it this way to avoid displaying copyrighted images.

#psychedelics #drugpolicy #UN #psychedelicresearch #historicalanalysis

They served us. Now we serve them. Veterans and first responders deserve every tool available for mental health— including safe, research-backed psychedelic therapy. It’s time to move from stigma to solutions. 🇺🇸 #Veterans #FirstResponders #MentalHealth #PsychedelicResearch #PTSD #EndTheStigma
https://psychedelicmentalhealth.net/moderating-factors-in-psilocybin-assisted-treatment-affecting-mood-and-personality-a-naturalistic-open-label-investigation-irrmischer-et-al-2025/ Moderating factors in #psilocybin -assisted treatment affecting mood and personality: A naturalistic, open-label investigation (Irrmischer, et al, 2025)
"Findings indicate that individual psilocybin-assisted therapy has the potential for beneficial effects on mood and personality characteristics. Moreover, the study highlights the importance of subjective experiences and demographic factors in moderating this effect." #psychedelicresearch #consciousness #neuroscience
Moderating factors in psilocybin-assisted treatment affecting mood and personality: A naturalistic, open-label investigation (Irrmischer, et al, 2025)

"Findings indicate that individual psilocybin-assisted therapy has the potential for beneficial effects on mood and personality characteristics. Moreover, the study highlights the importance of subjective experiences and demographic factors in moderating this effect."

Psychedelic Institute of Mental Health & Family Therapy
https://psychedelicmentalhealth.net/intravenous-ketamine-versus-esketamine-for-depression-a-systematic-review-and-meta-analysis-elmosalamy-et-al-2025/ "Based on the currently available comparative evidence, which is almost entirely observational, IV ketamine and IN esketamine show comparable acute response and remission rates, though IV ketamine may act faster. Large head-to-head RCTs are needed to confirm these findings." (Salamy, 2025) #ketamine #psychedelicresearch #ketaminetherapy #mentalhealth #depression #neuroscience #metaanalysis
Intravenous ketamine versus esketamine for depression: a systematic review and meta-analysis (Elmosalamy, et al, 2025)

"Based on the currently available comparative evidence, which is almost entirely observational, IV ketamine and IN esketamine show comparable acute response and remission rates, though IV ketamine may act faster."

Psychedelic Institute of Mental Health & Family Therapy
https://psychedelicmentalhealth.net/personality-profiles-and-trauma-history-in-ketamine-therapy-for-mood-and-anxiety-disorders-a-latent-profile-analysis-of-short-term-outcomes-gregoire-et-al-2025/ Personality profiles and trauma history in ketamine therapy for mood and anxiety disorders: A latent profile analysis of short-term outcomes (Gregoire, et al, 2025) While all profiles showed improvements in depression and anxiety one-week post-treatment, the personality profiles did not predict differential symptom change. #ketamine #trauma #depression #anxiety #mentalhealth #psychedelicresearch #psychedelics
Spotlight: Personality profiles and trauma history in ketamine therapy for mood and anxiety disorders: A latent profile analysis of short-term outcomes (Gregoire, et al, 2025)

"Personality traits relate to baseline mental health severity but not short-term response to ketamine. Trauma history may predict greater benefit from treatment."

Psychedelic Institute of Mental Health & Family Therapy
https://psychedelicmentalhealth.net/how-does-ketamine-affect-psychotherapy/ How does ketamine affect psychotherapy?
Studies suggest that human support is a factor in ketamine psychedelic therapy #ketamine #psychedelic #ketaminetherapy #ketamineassistedpsychotherapy #psychedelicresearch
How does ketamine affect psychotherapy?

Studies suggest that human support is a factor in ketamine psychedelic therapy

Psychedelic Institute of Mental Health & Family Therapy