review article from 2019:
Who will carry out the tests that would be necessary for proper safety evaluation of food emulsifiers?
https://doi.org/10.1016/j.fshw.2019.04.001
"The earliest studies investigated the co-carcinogenic potential of surfactants. As early as in the 1950s, Wong and coworkers published that polysorbate 80, when fed together with a known carcinogen (a polycyclic aromatic hydrocarbon: methylcholanthrene) significantly potentiates the local as well as distant carcinogenic activity in mice [20]. As polysorbate alone did not show any carcinogenic activity, authors concluded that polysorbate is co-carcinogen. "
...
"The impacts of surfactants on intestinal barriers were investigated already in the 1980’s. Tagesson et al. [24] in 1984 warned that surface-active food additives might impair the function of the mucosal barrier and increase the permeability of the gut to potentially toxic and pathogenic substances. In this paper polysorbate 60 and polysorbate 80 were studied on rat intestinal mucosa and found mucosal damage and increased permeability. It should be noted that this paper warned more than 30 years ago that increased absorption of macromolecules may facilitate the development of celiac disease, inflammatory bowel diseases and food allergy. Let us quote verbatim from their conclusion: 'it is possible that certain food additives may facilitate the intestinal absorption of potentially toxic and pathogenic compounds. This possibility should not be overlooked, since alterations in intestinal permeability may underlie a variety of diseases, not only in the gastro-intestinal tract itself but at distant sites such as the liver and joints.' Unfortunately, too little attention has been paid to this very important suggestion at that time."
#health #FoodAdditives #emulsifiers #surfactants
#Celiac #allergy #cancer
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