CellBioNewsApr 24, 2024

Researchers unveil #PI3K #enzyme's dual accelerator and brake mechanisms.

#cell_migration #signalling #endocytosis #p85β #AP2

https://phys.org/news/2024-04-unveil-pi3k-enzyme-dual-mechanisms.html

Researchers unveil PI3K enzyme's dual accelerator and brake mechanisms

A group of researchers have expanded conventional knowledge on a critical enzyme that controls cell migration. In a publication in the journal Nature Communications, they reported that phosphoinositide 3-kinase (PI3K) not only acts as an accelerator to prompt cell motility, but it also has a built-in brake mechanism that impedes migration.

Phys.org
Javier Díaz-NidoMay 31, 2023

Un nuevo fármaco en investigación aumenta el crecimiento neuronal en células nerviosas

#Neurociencia #Cerebro #Neurología #EnfermedadesNeurológicas #EnfermedadesNeurodegenerativas #Neurodegeneración #LesiónMedular #Ictus #RegeneraciónNerviosa #CrecimientoNeuronal #Neurona #FactoresNeurotróficos #PI3K #Quinasa
#Biomedicina #Salud

https://www.infosalus.com/salud-investigacion/noticia-nuevo-farmaco-investigacion-aumenta-crecimiento-neuronal-celulas-nerviosas-20230530074247.html

Un nuevo fármaco en investigación aumenta el crecimiento neuronal en células nerviosas

Una investigación liderada por el University College de Londres (UCL), en colaboración con el Laboratorio...

infosalus.com
Matt WillemsenMay 26, 2023
Unveiling ‘1938’: A Groundbreaking Compound for Nerve Regeneration and Heart Protection
Scientists from UCL, MRC LMB, and AstraZeneca have found a compound, named ‘1938’, that boosts nerve regeneration after injury and shields heart tissue from significant damage. The compound stimulates the PI3K signaling pathway linked to cell growth
https://scitechdaily.com/unveiling-1938-a-groundbreaking-compound-for-nerve-regeneration-and-heart-protection/ #1938 #nerve #regeneration ##HeartTissue #PI3K
Unveiling ‘1938’: A Groundbreaking Compound for Nerve Regeneration and Heart Protection

Scientists from UCL, MRC LMB, and AstraZeneca have found a compound, named '1938', that boosts nerve regeneration after injury and shields heart tissue from significant damage. The compound, which stimulates the PI3K signaling pathway linked to cell growth, represents a promising avenue for therapie

SciTechDaily
CellBioNewsApr 12, 2023

When #cells #sense the cue for #growth.

#PI3K #mTOR

https://phys.org/news/2023-04-cells-cue-growth.html

When cells sense the cue for growth

Researchers of the Genome Dynamics Project team at Tokyo Metropolitan Institute of Medical Science have revealed a new mechanism controlling cellular proliferation in response to serum, which triggers growth of resting cells.

Phys.org
The EMBO JournalJan 16, 2023

Cover feature in issue 42/2:

#Golgi #oxygen sensor controlling #intestinal ‘mucin #glycosylation
by Tal Ilani, Deborah Fass and colleagues with SciStories.com

And:
Gut colonization via #GTPase-less EF-G paralog
#Yeast cells in two minds about #cellcycle start
#MASTL/#PP2A module restraining #PI3K-Akt
Zinc-dependent structural transition in ALS-mutated #SOD1
https://www.embopress.org/toc/14602075/2023/42/2

Marco RadiNov 30, 2022
A fantastic #review on #lipidkinases by John #Burke and colleagues.
#PI3K #PI4K #PIKfyve
https://www.nature.com/articles/s41573-022-00582-5