Have you heard of sugar alcohols, such as erythritol, sorbitol, mannitol and xylitol? These are commonly used as artificial sweeteners. Learn more about these interesting small sugars and where they are found in our latest blog post, https://research.bidmc.org/ncfg/blog/23-facts-about-sugar-alcohols
#glycans #glycotime #glycosylation #science #artificialsweeteners
🤯 Did you know proteins inside cells can be glycosylated?! 🔬 Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in everything from gene expression to cell survival. Learn about O-GlcNAc & more!
👉 https://research.bidmc.org/ncfg/blog/21-facts-about-intracellular-protein-glycosylation
#glycans #proteinmodification #glycosylation #posttranslationalmodification #cellbiology #science #glycotime
Gut #bacteria can alter #brain #proteins: New #glycosylation method uncovers link.
https://phys.org/news/2025-02-gut-bacteria-brain-proteins-glycosylation.html
Our guts are home to trillions of bacteria, and research over the last few decades has established how essential they are to our physiology—in health and disease. A new study from EMBL Heidelberg researchers shows that gut bacteria can bring about profound molecular changes in one of our most critical organs—the brain.
Keyhole Limpet Hemocyanin (KLH) is used to produce #antibodies and as an #immunostimulant. Interestingly 3-4% of it's weight is #carbohydrate.
In this month's interesting facts about #glycans we take a look at the unusual #glycosylation of KLH.
Read at: https://research.bidmc.org/ncfg/blog/facts-about-keyhole-limpet-hemocyanin-klh-and-its-unusual-glycosylation
Immune Evasion, #Cell-Cell #Fusion, and #Spike Stability of the #SARS-CoV-2 #XEC #Variant: Role of #Glycosylation #Mutations at the N-terminal Domain
Source: BioRxIV, AbstractSARS-CoV-2 continues to evolve, producing new variants that drive global COVID-19 surges. XEC, a recombinant of KS.1.1 and KP.3.3, contains T22N and F59S mutations in the spike protein's N-terminal domain (NTD). The T22N mutation, similar to the DelS31 mutation in KP.3.1.1, introduces a potential…
Source: BioRxIV, AbstractSARS-CoV-2 continues to evolve, producing new variants that drive global COVID-19 surges. XEC, a recombinant of KS.1.1 and KP.3.3, contains T22N and F59S mutations in the s…
Glycosylation Modulates the Structure and Functions of Collagen: A Review (2024)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11012932/
#collagen #ConnectiveTissue #ExtracellularMatrix #glycosylation #glycobiology
Collagens are fundamental constituents of the extracellular matrix and are the most abundant proteins in mammals. Collagens belong to the family of fibrous or fiber-forming proteins that self-assemble into fibrils that define their mechanical properties ...
In this month's interesting facts about #glycans we look at the #glycoprotein collagen and its unique #glycosylation
Read the post: https://research.bidmc.org/ncfg/blog/facts-about-collagen-and-its-glycosylation-one-most-common-glycoproteins-all-animals
For more interesting facts check: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans
#Hemagglutinin #glycosylation pattern-specific effects: implications for the #fitness of H9.4.2.5-branched #H9N2 avian #influenza viruses, Emerg Microbes Infect.: https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2364736
Overall, our study provides a systematic insight into how changes in HA glycosylation patterns regulate the evolutionary fitness and epidemiological dominance drift of h9.4.2.5-branched H9N2 AIVs, which will be of great benefit for the glycosylation-dependent vaccine design.
NCFG
CellBioNews
Giuseppe Michieli
StructuralBiology
Rhyothemis