Role of #PCIF1-mediated 5′-cap N6-#methyladeonsine #m6A #mRNA #methylation in #colorectalcancer and anti-#PD1 #immunotherapy
New article by Tariq Rana and colleagues at UCSD
Thirty years ago, in November 1992, Ishida, Honjo and their collaborators reported the discovery of the #PD1 gene in @embojournal
https://www.embopress.org/doi/abs/10.1002/j.1460-2075.1992.tb05481.x
I spoke with Tasuku Honjo, Pierre Golstein (whose team first cloned #CTLA4) & Facundo Batista about the discovery earlier this year.
The initial project had absolutely nothing to do with checkpoints or #immunotherapy
Listen to the full #EMBOPodcast episode at the link below or on pretty much any podcast app
#Immunology #HistoryScience #Cancer #CellDeath
https://www.embo.org/podcasts/from-cell-death-to-cancer-immunotherapy/
#Immunology #Immunotherapy
#checkpointinhibitors
"In this Review we mark the tenth anniversary of the approval of ipilimumab and discuss the foundational scientific history of ICB, together with the history of the discovery, development and elucidation of the mechanism of action of the first generation of drugs targeting the #CTLA4 and #PD1 pathways."
This Perspective on cancer immunotherapy marks the tenth anniversary of the approval of the first immune checkpoint blockade (ICB) drug, ipilimumab, revisiting the history of the discovery, development and elucidation of the mechanism of action of the first generation of drugs targeting the CTLA4 and PD1 pathways.
halama_immuno
The EMBO Journal
Thiago Carvalho
C. Harris Floudas
Filip Janku
Dan Chen