David OjciusLactic acid drives #NLRP3 #inflammasome activation and caspase-1–like cytokine cleavage via intracellular acidification
https://www.nature.com/articles/s41419-026-08708-y #OpenAccess #immunology
The EMBO Journal#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481
https://www.embopress.org/doi/full/10.15252/embj.2023113481
Which #immune pathways (beyond #TLRs) control #otitis media and #COPD-inducing #Moraxella catarrhalis #infection?
Si-Ming Man and colleagues from Australian National University reveal requirement for #guanylate-binding GBP proteins and #caspase11-#NLRP3 #inflammasomes
Giuseppe Michieli
Thiago Carvalho'Gefitinib (GF), the tyrosine kinase inhibitor (TKI) targeting epidermal growth factor receptor, initiates lung #inflammation through the NLR family pyrin domain containing 3 (NLRP3) inflammasome. However, the molecular targets and mechanisms underlying the inflammatory action of GF remain unknown. In this study, we identified mitochondrial Src family kinases (mSFKs) as key determinants of GF-induced #NLRP3 #inflammasome activation.'
NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases
Key Points. The tyrosine kinase inhibitors (TKIs) act as agonists for the NLRP3 inflammasome.The TKIs exhibit off-target activity against c-Src, Fgr, and Fyn.Hy
C. Harris FloudasRT @CancerDoc: #NLRP3 #inflammasome is a double-edged sword in #cancer. NLRP3 activation can be associated with hyper-progression on #PD1 #immunotherapy https://www.science.org/doi/abs/10.1126/scitranslmed.abq7019
#oncology
#oncology
Filip Janku#NLRP3 #inflammasome is a double-edged sword in #cancer. NLRP3 activation can be associated with hyper-progression on #PD1 #immunotherapy https://www.science.org/doi/abs/10.1126/scitranslmed.abq7019