Which #immune pathways (beyond #TLRs) control #otitis media and #COPD-inducing #Moraxella catarrhalis #infection?

Si-Ming Man and colleagues from Australian National University reveal requirement for #guanylate-binding GBP proteins and #caspase11-#NLRP3 #inflammasomes

https://www.embopress.org/doi/10.15252/embj.2022112558

'Gefitinib (GF), the tyrosine kinase inhibitor (TKI) targeting epidermal growth factor receptor, initiates lung #inflammation through the NLR family pyrin domain containing 3 (NLRP3) inflammasome. However, the molecular targets and mechanisms underlying the inflammatory action of GF remain unknown. In this study, we identified mitochondrial Src family kinases (mSFKs) as key determinants of GF-induced #NLRP3 #inflammasome activation.'

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200611/238968/The-NLRP3-Inflammasome-Works-as-a-Sensor-for?redirectedFrom=fulltext