Mastodawn

Glibenclamide attenuates neuronal #pyroptosis by modulating KATP channels in the hippocampus of palmitic acid-induced lipotoxic mice

https://www.sciencedirect.com/science/article/pii/S2319417026000284 #OpenAccess #inflammasome #inflammation #immunology

David Ojcius Mar 21

Caspase-4 binds to #LPS membranes with positive curvature for non-canonical #inflammasome activation

https://www.sciencedirect.com/science/article/pii/S1074761325005734 #inflammation #immunity #immunology

PLOS Biology Sep 9, 2025

Even with #antiretroviral therapy, HIV-1 can still cause persistent inflammation in macrophages. This study shows that intron-containing #HIV1 RNA (icRNA) activates NLRP1 #inflammasome & induces IL-1β secretion in myeloid cells, independent of RIG-I-like receptors @PLOSBiology https://plos.io/45VTGBR

preLights May 28, 2025

Why do preterm neonates struggle to control sepsis?

“This study provides insight into how Krüppel-like factor 2 (KLF2) is involved” and shows that “KLF2 is a promising target in successfully treating newborns with sepsis.”

#preLight from Sydney Call & Sahan Senanayaka #ImmunobiologyUA ! ⬇️ 👀

👉 https://prelights.biologists.com/highlights/neutrophil-klf2-regulates-inflammasome-dependent-neonatal-mortality-from-endotoxemia/

#immunology #sepsis #biology #therapeutics #endotoxemia #inflammasome

PLOS Biology Feb 4, 2025

What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy plosbiology https://plos.io/42FTqFO

VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy

Although NLRP3 inflammasome activation and impaired autophagy are linked to inflammatory bowel disease (IBD), the underlying mechanisms remain unclear. This study shows that VANGL2 reduces IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation through OPTN-mediated autophagy.