David OjciusLactic acid drives #NLRP3 #inflammasome activation and caspase-1–like cytokine cleavage via intracellular acidification
https://www.nature.com/articles/s41419-026-08708-y #OpenAccess #immunology
Glibenclamide attenuates neuronal #pyroptosis by modulating KATP channels in the hippocampus of palmitic acid-induced lipotoxic mice
https://www.sciencedirect.com/science/article/pii/S2319417026000284 #OpenAccess #inflammasome #inflammation #immunology
Caspase-4 binds to #LPS membranes with positive curvature for non-canonical #inflammasome activation
https://www.sciencedirect.com/science/article/pii/S1074761325005734 #inflammation #immunity #immunology
PLOS BiologyEven with #antiretroviral therapy, HIV-1 can still cause persistent inflammation in macrophages. This study shows that intron-containing #HIV1 RNA (icRNA) activates NLRP1 #inflammasome & induces IL-1β secretion in myeloid cells, independent of RIG-I-like receptors @PLOSBiology https://plos.io/45VTGBR
preLightsWhy do preterm neonates struggle to control sepsis?
“This study provides insight into how Krüppel-like factor 2 (KLF2) is involved” and shows that “KLF2 is a promising target in successfully treating newborns with sepsis.”
#preLight from Sydney Call & Sahan Senanayaka #ImmunobiologyUA ! ⬇️ 👀
#immunology #sepsis #biology #therapeutics #endotoxemia #inflammasome
What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy plosbiology https://plos.io/42FTqFO
VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy
Although NLRP3 inflammasome activation and impaired autophagy are linked to inflammatory bowel disease (IBD), the underlying mechanisms remain unclear. This study shows that VANGL2 reduces IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation through OPTN-mediated autophagy.
Cell Chemical BiologyThe hydrophobicity of the #CARD8 N-terminus tunes #inflammasome activation by @LydiaTsams, @DBachovchin, and colleagues at @MSKCancerCenter @WeillCornellGS @TPCB_NYC https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00223-X?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
jobRxivPostdoc in Inflammasome Signaling
University of Antwerp
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576
#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576
Postdoc in Inflammasome Signaling
University of Antwerp
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142
#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142
Postdoc in Inflammasome Signaling
University of Antwerp
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239
#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239