Cambridge researchers use human organoids to restore nerve regeneration
📰 Original title: Human organoids reveal how to reverse "irreversible" nerve damage
🤖 IA: It's clickbait ⚠️
👥 Users: It's clickbait ⚠️
View full AI summary https://en.killbait.com/cambridge-researchers-use-human-organoids-to-restore-nerve-regeneration.html?utm_source=mastodon_world&utm_medium=social&utm_campaign=killbait.mastodon_world
#neuroscience #nerveregeneration #organoids
Cambridge researchers use human organoids to restore nerve regeneration
Scientists at the University of Cambridge have developed miniature lab-grown brain and spinal cord systems, called organoids, which mimic the human nervous system's communication pathways. Using these models, researchers discovered that human neurons gradually lose their ability to regrow after damage as they mature, a limitation that contributes to permanent disabilities following brain or spinal cord injuries. The team identified a network of genes that acts as a biological switch, limiting axon growth during development. Remarkably, when key regulators in this network were blocked, neurons regained their ability to regenerate. The study also identified an existing hormone drug, lynestrenol, which significantly enhanced axon regrowth in damaged neurons. While scar tissue and inflammation still pose challenges for repair, the findings indicate that targeting neuron-specific mechanisms could eventually allow recovery from injuries previously deemed irreversible. This research highlights the value of human organoids, which more accurately model human biology than animal studies, and offers potential pathways for developing future therapies for spinal cord injuries and neurodegenerative diseases. These advances could transform approaches to paralysis, multiple sclerosis, and motor neuron disorders, bridging a critical gap between lab research and patient treatment.
Cambridge researchers use human organoids to restore nerve regeneration
📰 Original title: Human organoids reveal how to reverse "irreversible" nerve damage
🤖 IA: It's clickbait ⚠️
👥 Users: It's clickbait ⚠️
View full AI summary https://en.killbait.com/cambridge-researchers-use-human-organoids-to-restore-nerve-regeneration.html?utm_source=mastodon_social&utm_medium=social&utm_campaign=killbait.mastodon_social
#neuroscience #nerveregeneration #organoids
Cambridge researchers use human organoids to restore nerve regeneration
Scientists at the University of Cambridge have developed miniature lab-grown brain and spinal cord systems, called organoids, which mimic the human nervous system's communication pathways. Using these models, researchers discovered that human neurons gradually lose their ability to regrow after damage as they mature, a limitation that contributes to permanent disabilities following brain or spinal cord injuries. The team identified a network of genes that acts as a biological switch, limiting axon growth during development. Remarkably, when key regulators in this network were blocked, neurons regained their ability to regenerate. The study also identified an existing hormone drug, lynestrenol, which significantly enhanced axon regrowth in damaged neurons. While scar tissue and inflammation still pose challenges for repair, the findings indicate that targeting neuron-specific mechanisms could eventually allow recovery from injuries previously deemed irreversible. This research highlights the value of human organoids, which more accurately model human biology than animal studies, and offers potential pathways for developing future therapies for spinal cord injuries and neurodegenerative diseases. These advances could transform approaches to paralysis, multiple sclerosis, and motor neuron disorders, bridging a critical gap between lab research and patient treatment.
#PhysCell Conference, 7–11 September 2026 in Egmond aan Zee, a lovely beach location in the #netherlands
Deadline May 8, 2026.
https://meetings.embo.org/event/26-physcell
Conference topics include:
* #Mechanics and #dynamics of #membranes, #cells, #tissues, and #organoids
* Reconstituted systems and synthetic cells
* #Biomolecular condensates
* #Physics of #chromosomes and the #nucleus
* Sensing and information in #livingCells
See you there!
A recent study utilizes 3D human brain
#organoids to investigate how the widely used antiepileptic drug valproate disrupts early fetal brain development and contributes to neurodevelopmental disorders.
#Neuroscience #Neuropharmacology #DevelopmentalBiology #sflorg https://www.sflorg.com/2026/04/ns04302601.html
Model study on the antiepileptic drug valproate: Influence on early brain development
3D brain organoid study reveals the mechanisms behind the antiepileptic drug valproate's disruption of fetal brain development.
Great work from our PhD student Bea for her talk at the #LifeSciencePhDmeeting on neuronal population growth dynamics in #organoids. And congratulations to our Master student Lara for winning the best picture award. There were also amazing poster contributions from our lab members.
#science #lifescience #PhD #microscope #microscopephotography #conference @uniinnsbruck
These Mini Brains Just Learned to Solve a Classic Engineering Problem
In a step toward biological computing, brain organoids rewired their networks as they learned to balance a digital pole on a cart.
Can ‘mini brains’ replace lab animals? Organoids are changing how scientists study disease | The-14
Lab-grown organoids offer a humane alternative to animal testing, helping scientists study diseases more accurately and advance personalized medicine research.
“These “mini organs” are grown from human stem cells and can reproduce some of the complex cell types and interactions found in the body. Because they’re derived from human cells, organoids offer researchers a way to study human diseases more directly than traditional animal models.”
#Science #Scicomm #Organoidshttps://theconversation.com/can-mini-brains-replace-lab-animals-organoids-are-changing-how-scientists-study-disease-277611
Can ‘mini brains’ replace lab animals? Organoids are changing how scientists study disease
Around 200 million animals are used in lab research around the world each year. Organoids may one day replace them.
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