Researchers have identified a novel cluster of liver cells (hepatocytes) that specifically emerge during metabolic dysfunction-associated steatohepatitis (MASH). These cells exhibit unique gene expression and cellular senescence, acting as a critical regulator of liver disease progression.
#Hepatology #CellBiology #DevelopmentalBiology #MolecularGenetics #sflorg
https://www.sflorg.com/2026/05/bio05042601.html
New Liver Cell Discovered to Protect Against MASH

Researchers discovered a novel liver cell utilizing the THEMIS gene to protect against MASH, offering a new therapeutic target for liver disease.

Light Shines on Embryonic Vulnerability

New research shows zebrafish embryos are most vulnerable to cell division errors just before the gastrula stage. Learn how this affects early development.

#ZebrafishResearch, #EmbryonicDevelopment, #CellDivision, #DevelopmentalBiology, #GastrulaStage

https://newsletter.tf/zebrafish-embryo-cell-division-errors-vulnerable/

Zebrafish embryos are much more sensitive to cell division errors before they reach the gastrula stage. This is a key finding for understanding early development.

#ZebrafishResearch, #EmbryonicDevelopment, #CellDivision, #DevelopmentalBiology, #GastrulaStage
https://newsletter.tf/zebrafish-embryo-cell-division-errors-vulnerable/

Zebrafish Embryo Cell Division Errors Most Harmful Before Gastrula Stage

New research shows zebrafish embryos are most vulnerable to cell division errors just before the gastrula stage. Learn how this affects early development.

NewsletterTF
A recent study utilizes 3D human brain #organoids to investigate how the widely used antiepileptic drug valproate disrupts early fetal brain development and contributes to neurodevelopmental disorders.
#Neuroscience #Neuropharmacology #DevelopmentalBiology #sflorg
https://www.sflorg.com/2026/04/ns04302601.html
Model study on the antiepileptic drug valproate: Influence on early brain development

3D brain organoid study reveals the mechanisms behind the antiepileptic drug valproate's disruption of fetal brain development.

Researchers at the University of Queensland have discovered that the disruption of a specific cellular protein, known as PRICKLE1, directly impairs the formation of the neural tube during embryonic development. This disruption prevents the upper and lower sections of the spinal cord from fusing correctly, resulting in junctional neural tube defects.
#Embryology #DevelopmentalBiology #Teratology #MolecularBiology #sflorg
https://www.sflorg.com/2026/04/bio04292601.html
Quail embryos + a prickly protein = major discovery in birth defects

Researchers observed in real time how disruption from a cell protein during neural tube formation causes birth defects like spina bifida.

Ocular coloboma is a congenital eye defect that occurs when the optic fissure fails to close properly during early development. Recent research utilizing lab-grown, miniature human retinas—known as retinal organoids—has identified how mutations in a specific growth-controlling protein contribute to this condition.
#MolecularGenetics #DevelopmentalBiology #Ophthalmology #sflorg
https://www.sflorg.com/2026/04/gen04132601.html
Lab-grown retina gives gene change clue to rare childhood eye condition

Coloboma arises when a structure in the developing eye, the optic fissure, fails to close properly and often co‑occurs with other tissue‑fusion proble

The nutritional environment of mother nematodes directly dictates the early growth rate of their offspring by determining the quantity of ribosomes—cellular "protein factories"—passed down through the egg. If the maternal food supply is restricted, the offspring inherit fewer ribosomes, resulting in slower initial development.
#CellBiology #DevelopmentalBiology #Epigenetics #sflorg
https://www.sflorg.com/2026/04/cbio04102601.html
Nematodes show how lack of food shapes the next generation

Whether organisms grow quickly or slowly depends heavily on nutrient availability.

Postdoctoral position in the Perry Lab, UC San Diego

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We now know why a belly button becomes an 'innie'

Scientists have discovered a new abdominal structure called the umbilical sheath, which anchors the remnant of the umbilical cord to deep abdominal tissues and helps determine the shape of your navel

Pure Science News
We now know why a belly button becomes an 'innie'

Scientists have discovered a new abdominal structure called the umbilical sheath, which anchors the remnant of the umbilical cord to deep abdominal tissues and helps determine the shape of your navel

Pure Science News