Cambridge researchers use human organoids to restore nerve regeneration
📰 Original title: Human organoids reveal how to reverse "irreversible" nerve damage
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#neuroscience #nerveregeneration #organoids
Cambridge researchers use human organoids to restore nerve regeneration
Scientists at the University of Cambridge have developed miniature lab-grown brain and spinal cord systems, called organoids, which mimic the human nervous system's communication pathways. Using these models, researchers discovered that human neurons gradually lose their ability to regrow after damage as they mature, a limitation that contributes to permanent disabilities following brain or spinal cord injuries. The team identified a network of genes that acts as a biological switch, limiting axon growth during development. Remarkably, when key regulators in this network were blocked, neurons regained their ability to regenerate. The study also identified an existing hormone drug, lynestrenol, which significantly enhanced axon regrowth in damaged neurons. While scar tissue and inflammation still pose challenges for repair, the findings indicate that targeting neuron-specific mechanisms could eventually allow recovery from injuries previously deemed irreversible. This research highlights the value of human organoids, which more accurately model human biology than animal studies, and offers potential pathways for developing future therapies for spinal cord injuries and neurodegenerative diseases. These advances could transform approaches to paralysis, multiple sclerosis, and motor neuron disorders, bridging a critical gap between lab research and patient treatment.
Cambridge researchers use human organoids to restore nerve regeneration
📰 Original title: Human organoids reveal how to reverse "irreversible" nerve damage
🤖 IA: It's clickbait ⚠️
👥 Users: It's clickbait ⚠️
View full AI summary https://en.killbait.com/cambridge-researchers-use-human-organoids-to-restore-nerve-regeneration.html?utm_source=mastodon_social&utm_medium=social&utm_campaign=killbait.mastodon_social
#neuroscience #nerveregeneration #organoids
Cambridge researchers use human organoids to restore nerve regeneration
Scientists at the University of Cambridge have developed miniature lab-grown brain and spinal cord systems, called organoids, which mimic the human nervous system's communication pathways. Using these models, researchers discovered that human neurons gradually lose their ability to regrow after damage as they mature, a limitation that contributes to permanent disabilities following brain or spinal cord injuries. The team identified a network of genes that acts as a biological switch, limiting axon growth during development. Remarkably, when key regulators in this network were blocked, neurons regained their ability to regenerate. The study also identified an existing hormone drug, lynestrenol, which significantly enhanced axon regrowth in damaged neurons. While scar tissue and inflammation still pose challenges for repair, the findings indicate that targeting neuron-specific mechanisms could eventually allow recovery from injuries previously deemed irreversible. This research highlights the value of human organoids, which more accurately model human biology than animal studies, and offers potential pathways for developing future therapies for spinal cord injuries and neurodegenerative diseases. These advances could transform approaches to paralysis, multiple sclerosis, and motor neuron disorders, bridging a critical gap between lab research and patient treatment.
Study shows new chemical compound demonstrates potential in nerve regeneration
Research led by UCL, in partnership with the MRC Laboratory of Molecular Biology (MRC LMB) and AstraZeneca, has identified a new compound that can stimulate nerve regeneration after injury, as well as protect cardiac tissue from the sort of damage seen following a heart attack.
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