Sleep: It All Comes Down to the Mitochondria
https://www.science.org/content/blog-post/it-all-comes-down-mitochondria
https://news.ycombinator.com/item?id=44732020
#DerekLowe
Mitochondrial origins of the pressure to sleep
https://www.nature.com/articles/s41586-025-09261-y
#mitochondria #OXPHOS #metabolism #sleep #CellBiology #MolecularBiology #ATP
Upregulation of the mitochondrial calcium uniporter (MCU) has been shown to facilitate colorectal cancer cell growth, but the contributions of MCU-regulatory proteins are not known. These authors show that MICU2 ensures metabolic flexibility between anaerobic glycolysis and oxidative phosphorylation and regulates cancer cell proliferation.
Biologists travel with their mobile laboratory to study a wide range of #mitochondrial functions in #avian #migration.
#Zonotrichia #ETC #OXPHOS #MitoMobile
https://phys.org/news/2024-05-biologists-mobile-laboratory-wide-range.html
For Wendy Hood and Geoffrey Hill in Biological Sciences, Andreas Kavazis in Kinesiology, and their team, Emma Rhodes, Paulo Mesquita, and Jeff Yap, traveling the country to unlock the mystery of mitochondria in migrating aviary species has allowed them to make a significant contribution to research in an area that has not been investigated before.
What is the role of #DNAdamage #kinase #DNAPKcs in the cellular response to #oxidative stress?
Benjamin Chen at UT Southwestern, Hsinyu Lee at National Taiwan University, and coworkers implicate it as part of a #checkpoint that modulates #ANT2-#VDAC2-mediated ADP-ATP exchange over #mitochondrial membranes to limit #OXPHOS-derived ROS
Background: BCL-2 dependent leukemia-stem cells preferentially rely on oxidative phosphorylation (OXPHOS) as a source of energy (Pei et al Cancer Discovery 2020
Victoria Stuart 🇨🇦 🏳️⚧️
PLOS Biology
CellBioNews
The EMBO Journal
Alex Silver