What is the role of #DNAdamage #kinase #DNAPKcs in the cellular response to #oxidative stress?

Benjamin Chen at UT Southwestern, Hsinyu Lee at National Taiwan University, and coworkers implicate it as part of a #checkpoint that modulates #ANT2-#VDAC2-mediated ADP-ATP exchange over #mitochondrial membranes to limit #OXPHOS-derived ROS

https://www.embopress.org/doi/10.15252/embj.2022112094