Recent studies have shown that #AcuteMyeloidLeukemia favors #OxPhos metabolism. This #ASH22 abstract from my colleagues demonstrates with in vitro and in vivo models that the use of #ammocidin, an inhibitor of electron transport chain complex V, works synergistically with low-dose #venetoclax to kill #AML cells. Stop by poster 2652 or read more about it here: https://ashpublications.org/blood/article/140/Supplement%201/5959/492144/Electron-Transport-Chain-Complex-V-Inhibition #leukemia #cancer #oncology #hematology #hemonc #science #medicine
Electron Transport Chain Complex V Inhibition Enhances the Antileukemic Activity of Low-Dose Venetoclax in Acute Myeloid Leukemia
Background: BCL-2 dependent leukemia-stem cells preferentially rely on oxidative phosphorylation (OXPHOS) as a source of energy (Pei et al Cancer Discovery 2020
