Mastodawn

Small cell #neuroendocrine cancers, which frequently lack the tumor-suppressing RB gene, exhibit a critical dependency on the E2F3 protein for survival. This dependency creates a vulnerability known as synthetic lethality, where inhibiting E2F3 in RB-deficient cells effectively halts tumor growth and induces cancer cell death.
#Genetics #CellBiology #Oncology #Cancer #sflorg
https://www.sflorg.com/2026/03/gen03212601.html

Newly discovered genetic weakness may help target deadly small cell neuroendocrine cancers

UCLA researchers found blocking a key protein could halt tumor growth in aggressive cancers

Stefan F. Wirth Mar 17

RE: https://fediscience.org/@eLife/116235479359504132

About the #nuclear #porecomplex (#NPC) #protein #Nup107 regulating broader #neuroendocrine functions in #fly larval #brains. The authors J. Kawadkar et al. (2026) in experiments reduced the Nup107 protein that enables #moleculetransfer between nucleus and cellular cytoplasma in #fruitflies using suitable genetic tools. According to the authors, there is a wider context between the protein and larval #developmentalprocesses based on the #steroidhormone #ecdysone.

Scientific Frontline Oct 8

To better understand the role of #bacteria in the stomach, researchers collected #biopsies from patients with #autoimmune gastritis, both with and without #neuroendocrine #tumors, and compared their #microbial communities.
#Microbiology #sflorg
https://www.sflorg.com/2025/10/mcb10082501.html

Changes in gut microbiota influence which patients get AIG-related neuroendocrine tumors

Researchers found how changes in gut microbiota influence stomach health and even the growth of neuroendocrine tumors in autoimmune gastritis patients