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A year-long aerobic exercise program lowers long-term exposure to the stress hormone cortisol, as measured in hair samples, indicating reduced chronic stress. In a randomized trial with 130 healthy adults, those who completed 150 minutes of moderate to vigorous exercise weekly for a year showed lower accumulated hair cortisol than a non-exercising control group. Other health markers such as cholesterol, blood sugar, and inflammatory measures did not show meaningful changes in this healthy sample.

This work is of interest to psychology because it links sustained physical activity to long-term regulation of biological stress systems, highlighting how lifestyle factors can influence neuroendocrine and autonomic processes involved in emotion and stress processing.

Article Title: How a year of regular exercise alters the biology of stress

Link to PsyPost Article: https://www.psypost dot org/how-a-year-of-regular-exercise-alters-the-biology-of-stress/

Article Title: How a year of regular exercise alters the biology of stress
Link to PsyPost Article: https://www.psypost dot org/how-a-year-of-regular-exercise-alters-the-biology-of-stress/

Copy and paste broken link above into your browser and replace "dot" with "." for link to work. We have to do it this way to avoid displaying copyrighted images.

#ExerciseAndStress #HairCortisol #StressBiology #AutonomicNervousSystem #Neuroendocrine

Scientific Frontline Mar 21

Small cell #neuroendocrine cancers, which frequently lack the tumor-suppressing RB gene, exhibit a critical dependency on the E2F3 protein for survival. This dependency creates a vulnerability known as synthetic lethality, where inhibiting E2F3 in RB-deficient cells effectively halts tumor growth and induces cancer cell death.
#Genetics #CellBiology #Oncology #Cancer #sflorg
https://www.sflorg.com/2026/03/gen03212601.html

Newly discovered genetic weakness may help target deadly small cell neuroendocrine cancers

UCLA researchers found blocking a key protein could halt tumor growth in aggressive cancers

Stefan F. Wirth Mar 17

RE: https://fediscience.org/@eLife/116235479359504132

About the #nuclear #porecomplex (#NPC) #protein #Nup107 regulating broader #neuroendocrine functions in #fly larval #brains. The authors J. Kawadkar et al. (2026) in experiments reduced the Nup107 protein that enables #moleculetransfer between nucleus and cellular cytoplasma in #fruitflies using suitable genetic tools. According to the authors, there is a wider context between the protein and larval #developmentalprocesses based on the #steroidhormone #ecdysone.

Scientific Frontline Oct 8, 2025

To better understand the role of #bacteria in the stomach, researchers collected #biopsies from patients with #autoimmune gastritis, both with and without #neuroendocrine #tumors, and compared their #microbial communities.
#Microbiology #sflorg
https://www.sflorg.com/2025/10/mcb10082501.html

Changes in gut microbiota influence which patients get AIG-related neuroendocrine tumors

Researchers found how changes in gut microbiota influence stomach health and even the growth of neuroendocrine tumors in autoimmune gastritis patients