I published a new post, this time trying to make the most of the little RAM I had to create a #TileDB #soma - a #singlecell format and database - but for the complete #LINCS 2020 dataset. A measly 140GB+ of data.

I didn't want to re-invent the wheel, so ended converting between multiple file formats to avoid as many in-memory operations as possible.

https://amjdomingues.com/posts/2025-11-02-cmap-tile-db-build/

There are probably less evolved ways of doing this, but this is the one my technical skills allowed:)

#RStats

Historically, Lincolnshire, like Gaul, “est omnis divisa in partes tres”. In terms of local government reorganisation in England, this should obviously be the model for unitarisation in the county* - https://en.m.wikipedia.org/wiki/Parts_of_Lincolnshire

* given the distribution of modern population and infrastructure, this is probably untrue/a bad idea, but I’m unsure if there is a “good” way to do it. However it is probably the one that could best be pitched to the very conservative/Conservative locals.

#UKPol #UKPolitics #LocalGovernmentReorganisation #Lincolnshire #Lincs

📍: Bridge 18
ℹ️: road bridge
🗺: https://www.openstreetmap.org/?mlat=52.9815440741793&mlon=-0.029736970169721#map=17/52.9815440741793/-0.029736970169721
📸: Photo by Billy Wilson Photography on Flickr https://www.flickr.com/photos/32132568@N06/49781943018

#canal #narrowboat #england #uk #flickr #2019 #adventure #biketour #cycling #europe #bike #tour #united #kingdom #british #britain #lincolnshire #lincs #architecture #historic #boston #church #gothic #stone #religious

📍: Tidal Wharf
ℹ️: wharf
🗺: https://www.openstreetmap.org/?mlat=52.9829372887381&mlon=-0.032429598109636#map=17/52.9829372887381/-0.032429598109636
📸: Photo by Billy Wilson Photography on Flickr https://www.flickr.com/photos/32132568@N06/49782547966

#canal #narrowboat #england #uk #flickr #cycling #europe #adventure #biketour #2019 #bike #tour #britain #united #kingdom #british #boston #architecture #historic #lincolnshire #lincs

📍: Tidal Wharf
ℹ️: wharf
🗺: https://www.openstreetmap.org/?mlat=52.9829372887381&mlon=-0.032429598109636#map=17/52.9829372887381/-0.032429598109636
📸: Photo by Billy Wilson Photography on Flickr https://www.flickr.com/photos/32132568@N06/49782547966

#canal #river #narrowboat #barge #gongoozler #england #uk #flickr #cycling #europe #adventure #biketour #2019 #bike #tour #britain #united #kingdom #british #boston #architecture #historic #lincolnshire #lincs

Can ChatGPT predict DNA mutations from RNA expression values?

A #preprint #CompProteomics shows that training a deep learning model with 978 transcript levels is sufficient to predict which gene got silenced following shRNA knockdown!

#preLight by Raquel Moya 👉 https://prelights.biologists.com/highlights/modeling-transcriptional-profiles-of-gene-perturbation-with-a-deep-neural-network/

#bioinformatics #cmap #crispr #DeepLearning #lincs #llm #MachineLearning #NeuralNetwork #shrna

https://www.instagram.com/p/C1UtBg8s_15/

#parentblogger #kidsactivities #magicofchristmas #candidchildhood #oursimplesnaps #mrshinchhome #mamahoodinsquares #talesfromoutdoors #raisinglittlewilds #bryonyannie #natureseekers #kidsatchristmas #exploreoutdoors #festivevibes #festivedecor #singleparents #festiveactivities #christmastime #xmasdecorations #lincolnshirelife #snippetsofplay #parentblogs #unitedkingdom #kidswhoexplore #naturalchildhood #christmastradition #thatparentlife #fatherchristmascame #lincs

https://www.instagram.com/p/C1P8Tv8M2Mv/

#parentblogger #motherhoodandmeshare #magicofchristmas #candidchildhood #oursimplesnaps #mrshinchhome #mamahoodinsquares #talesfromoutdoors #raisinglittlewilds #yourblendedfamily #natureseekers  #countryhumans #exploreoutdoors #festivevibes #festivedecor #singleparent #festiveactivities #christmastime #xmasdecorations #lincolnshirelife #snippetsofplay #parentblogs #unitedkingdom #kidswhoexplore #naturalchildhood #christmastradition #thatparentlife #fatherchristmas #lincs