Insights on #geroscience pre-clinical and clinical #trials to promote healthy #aging from the Intrinsic Capacity, #Frailty and Sarcopenia #Research Task Force 2025
#Ageing #IntrinsicCapacity #Sarcopenia #Science #Biology #Health
https://www.sciencedirect.com/science/article/pii/S2260134126000162?via%3Dihub
Multi-trajectories of intrinsic capacity and their impact on incident #disability in community-dwelling older adults in Japan
#Geriatrics #Frailty #IntrinsicCapacity #Ageing #Aging #Health #Care
https://www.sciencedirect.com/science/article/pii/S0167494326000762?dgcid=raven_sd_via_email
A #genome -wide association study identified 10 novel genomic loci associated with #IntrinsicCapacity.
👉Genetic architecture of #IC, laying the foundation for future #research on healthy #aging
#Geriatrics #Genes #Ageing #Health #Genetics
Full-text available here👇
https://academic.oup.com/biomedgerontology/article/80/11/glaf196/8277562
A blood-based #epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and #lifestyle factors
"...a validated tool bridging molecular readouts of #aging and clinical assessments of #IC..."
#IntrinsicCapacity #Frailty #Geriatrics #Ageing #Research #Science
Fuentealba and colleagues build and validate a DNA methylation clock of intrinsic capacity (IC) to bridge resource-intensive clinical assessments of IC with molecular readouts of aging, highlighting strong links to inflammation, clinical health markers and lifestyle factors.
Excellent output from an #EAMA project to support the teaching and dissemination of #IntrinsicCapacity to medical students.
#Geriatrics #Ageing #Aging #Health #Care #WHO #MedMastodon
Please use and share the brochure below (English version):
https://www.eama.eu/Uploads/Interactive-pdf-IC-1-4.pdf
...but also in French:
https://www.eama.eu/Uploads/Interactive-pdf-IC-1-4-FR.pdf
...and in Spanish:
https://www.eama.eu/Uploads/Interactive-pdf-IC-1-4-ES.pdf
#Frailty: a global #health challenge in need of local action
To me, a critical issue in frailty (and #IntrinsicCapacity) is realising the limited importance of tools in capturing the condition of interest.
Contextualise and be pragmatic; one (tool) will never fit all (globally).
Frailty is a complex, age-related clinical condition that involves multiple contributing factors and raises the risk of adverse outcomes in older people. Given global population ageing trends, the growing prevalence and incidence of frailty pose significant challenges to health and social care systems in both high-income and lower-income countries. In this review, we highlight the disproportionate representation of research on frailty screening and management from high-income countries, despite how lower-income countries are projected to have a larger share of older people aged ≥60. However, more frailty research has been emerging from lower-income countries in recent years, paving the way for more context-specific guidelines and studies that validate frailty assessment tools and evaluate frailty interventions in the population. We then present further considerations for contextualising frailty in research and practice in lower-income countries. First, the heterogeneous manifestations of frailty call for research that reflects different geographies, populations, health systems, community settings and policy priorities; this can be driven by supportive collaborative systems between high-income and lower-income countries. Second, the global narrative around frailty and ageing needs re-evaluation, given the negative connotations linked with frailty and the introduction of intrinsic capacity by the World Health Organization as a measure of functional reserves throughout the life course. Finally, the social determinants of health as possible risk factors for frailty in lower-income countries and global majority populations, and potential socioeconomic threats of frailty to national economies warrant proactive frailty screening in these populations. All data relevant to the study are included in the article.
Adverse outcomes of intrinsic capacity in older adults: A scoping #review
"This is the first scoping review to comprehensively summarize adverse outcomes of #IntrinsicCapacity in older adults..."
#Geriatrics #Frailty #Care #OlderPeople #Ageing #Health #PublicHealth #HealthyAgeing #Aging
https://www.sciencedirect.com/science/article/pii/S0167494324000116
Age-related changes in auditory perception. Hearing loss in the elderly: #aging ear or aging brain?
#Hearing #Ageing #Geriatrics #IntrinsicCapacity #Dementia #Neurology
Hearing loss in the elderly is a very common disease: it is estimated to affect up to a third of the population aged 65 years or more, and 50% of people over 75 years old. There is a growing amount of data concerning the association between hearing loss and cognitive decline. Various possible mechanisms at the basis of this association have been proposed, such as the “common cause hypothesis,” the “cascade hypothesis,” and the “cognitive load hypothesis.”Critically reviewing the data is essential to highlight the features of the relationship between hearing loss and cognitive decline. Most of the hearing tests available should take into account that dementia or even just mild cognitive impairment (MCI) may lead to poor performance during examination. On the other hand, clinicians should also remember that tests used to assess cognitive function require an adequate hearing capacity.In this article we propose to analyze current diagnostic tests, treatment options, auditory processing, and rehabilitation strategies for hearing loss in the elderly in order to facilitate the management of this handicap in this fragile population.
Sustained improvement of intrinsic capacity in community‐dwelling older adults: The +AGIL Barcelona multidomain program
A coordinated, multidisciplinary and integrated program can improve older adults’ #IntrinsicCapacity
#Health #Aging #Geriatrics
https://onlinelibrary.wiley.com/doi/10.1111/joim.13710
Matteo Cesari
Matteo Cesari 