Lipid #nanoparticles successfully delivered a full-length, healthy #CFTR gene into human airway cells, restoring essential biological function in a cystic #fibrosis model without the use of viral vectors.
#Medical #Nanotechnology #Nanomedicine #GeneTherapy #PulmonaryMedicine #sflorg
https://www.sflorg.com/2026/02/med02172601.html
Nanoparticle-based gene editing could expand treatment options for cystic fibrosis

Replacing the entire faulty gene rather than correcting individual mutations may allow the therapy to work across all patients with cystic fibrosis.

Inhibition of the epigenetic co-activators p300/CBP prevents alveolar type 2 (AT2) cells from becoming trapped in a pathogenic "alveolar transitional cell state" (ATCS), thereby blocking the progression of idiopathic #pulmonary #fibrosis (#IPF ).
#RegenerativeMedicine #Epigenetics #Genetics #Medical #sflorg
https://www.sflorg.com/2026/02/gen02142601.html
Disrupting pathogenic cell states to combat pulmonary fibrosis

A key regulatory mechanism driving idiopathic pulmonary fibrosis (IPF) and identified a promising therapeutic strategy.

¿Qué es la Aracnoiditis? - Somosdisc@

Hoy os explico que es a aracnoiditis, que implica inflamación y daño de la aracnoide, una de las capas del sistema nervioso central.

Somosdisc@
When #inflammation in the body goes unchecked, it can cause #fibrosis, or tissue scarring that may lead to organ dysfunction or even failure. This can happen in conditions such as inflammatory bowel diseases (ulcerative colitis and Crohn’s disease), chronic viral infections, interstitial lung fibrosis, chronic autoimmune skin diseases such as scleroderma, and scars associated with heart disease.
#MolecularBiology #Medical #sflorg
https://www.sflorg.com/2026/01/mbio01072601.html
Researchers uncover molecular roots of fibrosis or tissue scarring in inflammatory bowel disease

Scientists also identified the GLIS3 molecule as a master regulator of the crosstalk between immune and structural cells that gives rise to fibrosis.

Día Mundial de la Fibrosis Quística 2025 - Somosdisc@

Cada 8 de septiembre se celebra el día Mundial de la Fibrosis Quística, visibilizando esta enfermedad rara que afecta a 72.000 personas.

Somosdisc@

🧬 This Taiwanese biotech startup is taking on one of medicine’s toughest challenges: fibrosis.

With a groundbreaking nucleic acid therapy aimed at reversing lung scarring in diseases like IPF, they’re not just slowing damage — they’re targeting the root cause.

🔬 Read how this team could change the future of pulmonary care:

👉 https://www.sparknify.com/post/this-taiwanese-biotech-startup-is-taking-aim-at-fibrosis-with-a-groundbreaking-nucleic-acid-therapy

#Biotech #Fibrosis #IPF #RNAtherapy #TaiwanStartups #Healthtech #Sparknify

¿Qué es el Síndrome de la espalda fallida? - Somosdisc@

Hoy os hablaré de lo qué es el Síndrome de la espalda fallida, en que consiste, sus síntomas, causas y como disminuye la calidad de vida.

Somosdisc@

New insights into alcohol-related liver disease: in the recent preprint, we mapped niche-specific cell interactions at ultra-high resolution (2μm spots), described hepatic niche markers, and cell subtypes defined by them. Stay tuned!
#ALD #SpatialBiology #Fibrosis 🧪

https://www.biorxiv.org/content/10.1101/2025.03.15.643421v1.full.pdf+html

Spatial single-cell interactome and niche-specific molecular signatures in alcohol-related liver disease

Alcohol-related liver disease (ALD) remains a major global health burden with limited therapeutic options due to an incomplete understanding of its underlying molecular mechanisms and cellular crosstalk. Here, we applied ultra-high resolution (on 2μm spots) spatial transcriptomics to a cirrhotic liver tissue obtained from an end-stage ALD patient, analyzing >265,000 spatially resolved cells with further validation on single-cell and single-nuclei datasets from patients with ALD cirrhosis. Our analysis delineated distinct cellular sub-populations and molecular landscapes across fibrotic, vascular, and parenchymal niches of ALD cirrhosis. We identified robust zonation of hepatocytes, hepatic stellate cells, and diverse immune subpopulations, including enrichment of pro-inflammatory T cells and dendritic cells in the fibrotic niche and MARCO +; tissue-resident macro-phages localizing mostly in parenchymal areas. Analysis of spatial metrics assigned expression of WNT4 , RCAN3 , PPIAL4G , PLA2G5 , and SLC6A9 to the fibrotic environment in ALD. Differential expression and ligand-receptor interactome analyses revealed niche-specific signaling, with marked CCL19 - CCR7 activity in fibrotic regions and DLL4 - NOTCH3 crosstalk in vascular compartments. Notably, WNT4+; fibroblasts emerged as key mediators of extracellular matrix remodeling and chemoattraction, particularly via CCL19 -mediated signaling towards CD8 T cells, which was validated on single-cell resolution within the ALD cirrhotic liver in external datasets. These spatial and single-cell findings highlight novel potential therapeutic targets for patients with ALD cirrhosis. ### Competing Interest Statement The authors have declared no competing interest.

bioRxiv
Día Mundial de la Fibrosis Quística 2024 - Somosdisc@

Cada 8 de septiembre se celebra el día Mundial de la Fibrosis Quística, para visibilizar a esta enfermedad rara que afecta a 72.000 personas.

Somosdisc@

🔬🦴🩻🧪 Multifaceted bone response to immunomodulatory magnesium implants: Osteopromotion at the interface and adipogenesis in the bone marrow 🔍

https://doi.org/10.1016/j.biomaterials.2024.122779

#biomaterials #tissueengineering #regenerativemedicine #biology #implants #inflammation #immunomodulation #fibrosis #medicine #healthcare #engineering #magnesium #science

Multifaceted bone response to immunomodulatory magnesium implants: Osteopromotion at the interface and adipogenesis in the bone marrow

Orthopedic implants made of biodegradable magnesium (Mg) provide an alternative to nondegradable implants for fracture repair. Widely reported to be p…