Joanna MaselOct 30, 2024
Our new #preprint changes the way we look at an “extinction vortex” in which a small population loses fitness, causing it to become even smaller https://www.biorxiv.org/content/10.1101/2024.10.25.620329v1.
#MutationalMeltdown #EffectivePopulationSize #EvolutionaryRescue #PopulationGenetics #EvolGenPaper @wmawass @jdmatheson @uliseshmc 1/7
Joanna MaselSep 6, 2024
Our latest paper https://elifesciences.org/articles/87335
directly measures the #EffectivePopulationSize that matters to #NearlyNeutralTheory / #DriftBarrier theory, as the degree to which #CodonBias differs from expectations from GC content. Surprisingly, stronger #NaturalSelection -> higher #IntrinsicStructuralDisorder proteins
#MolecularEvolution #PopulationGenetics #EvolgenPaper 1/
The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder

Proteins evolve more intrinsic structural disorder under more effective selection, with selection assessed via a novel metric of codon adaptation.

eLife
Joanna MaselApr 12, 2024
Our latest #preprint https://ecoevorxiv.org/repository/view/6959/ explains why fitness can be defined in so many ways, and which version(s) you should use when. Fitness quantifies what #NaturalSelection favors. @gdoulcier #EvolGenPaper #Evolution 1/
Why there are so many definitions of fitness in models

Jeffrey Ross-IbarraJul 14, 2023
Such a cool system. A fun project to work on. First DMI in maize I believe. And cool meiotic drive, sRNA, and teosinte introgression. #EvolgenPaper https://www.biorxiv.org/content/10.1101/2023.07.12.548689v1
Joanna MaselJun 15, 2023
Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper
Dimitris KontopoulosApr 28, 2023

Delighted to share our new Science #EvolgenPaper! https://www.science.org/doi/10.1126/science.abn3107

We introduce #TOGA, a #ComparativeGenomics method that combines the detection of orthologous genes with gene annotation. In plain words, TOGA can take advantage of a well-annotated #genome and transfer its annotations to a genome of a different species (e.g., from the human genome to that of a squirrel). 1/2

Jeffrey Ross-IbarraApr 27, 2023

Neat new #EvolgenPaper by @gvbarroso.

The landscape of nucleotide diversity in Drosophila melanogaster is shaped by mutation rate variation:

https://peercommunityjournal.org/articles/10.24072/pcjournal.267/

Excited to sit down with this one!

The landscape of nucleotide diversity in Drosophila melanogaster is shaped by mutation rate variation

Joanna MaselApr 12, 2023
Our extensively revised preprint now goes beyond clarifying Haldane’s arguments about the #CostOfSelection / #SubstitutionalLoad / #SelectiveDeaths, it also significantly extends them, and applies the resulting model to data https://www.biorxiv.org/content/10.1101/2021.11.01.466728v2
@jdmatheson @moi #EvolgenPaper #PopulationGenetics #NaturalSelection #FitnessComponents #GeneticLoad 1/10
Andy FooteMar 27, 2023
Analyses of the first 'type D' killer whale genomes to be sequenced published online today in the Journal of Heredity. Over 65% of the autosomes are in long ROH making them among the most inbred mammals sequenced to date. https://doi.org/10.1093/jhered/esac070 #EvolgenPaper
“Type D” killer whale genomes reveal long-term small population size and low genetic diversity

Abstract. Genome sequences can reveal the extent of inbreeding in small populations. Here, we present the first genomic characterization of type D killer whales

OUP Academic
Katie LotterhosMar 15, 2023
Out today in PNAS: "The paradox of adaptive trait clines with nonclinal patterns in the underlying genes" https://www.pnas.org/doi/full/10.1073/pnas.2220313120 This study shows that under complex multivariate adaptation, trait clines can evolve despite nonmonotonic allele frequency patterns across environmental gradients. These patterns are not discovered by genotype–environment association methods, which are widely used to discover adaptation. #EvolutionPaper #EcoEvo #SLiM #Genetics #Genomics #EvolgenPaper #PopGen