Dimitris Kontopoulos

@DGKontopoulos@ecoevo.social
142 Followers
160 Following
243 Posts
Walter Benjamin Fellow @ UCLA with Noa Pinter-Wollman. Looking at the impacts of temperature changes on diverse biological systems. Also husband & dad.
Websitehttps://dgkontopoulos.io
ORCIDhttps://orcid.org/0000-0002-5082-1929
Pronounshe/him
Βluesky profile (bridged)https://bsky.app/profile/DGKontopoulos.ecoevo.social.ap.brid.gy
Dimitris Kontopoulos2d ago
Gregor Kalinkat2d ago

'Postdoc depression and anxiety rates are rising, finds survey of 872 researchers' @nature.com Career News

https://www.nature.com/articles/d41586-025-02450-9

#academia 🎓
#postdoc 🧪
#IchbinHanna 👩‍🔬

Postdoc depression and anxiety rates are rising, finds survey of 872 researchers

The Max Planck Society is good at attracting international postdocs but struggles to retain them, survey finds.

Dimitris Kontopoulos2d ago
Ayke van Laethem3d ago

Somehow landed on the NetBSD manpage of sleep(1) and they seem to have a rather unique take on what is considered a bug.

#netbsd

Dimitris Kontopoulos5d ago

On GitHub moving to integration with Microsoft's AI team (see https://ecoevo.social/@mcc@mastodon.social/115011101022724613).

Switch to @Codeberg. I recently made the move from GitHub to Codeberg to store code that reproduces the analyses of my latest paper (https://codeberg.org/dgkontopoulos/Kontopoulos_et_al_evolution_of_ADK_structures_2025), and I have no regrets.

From now on, I will only use GitHub to update my personal website, which runs on GitHub Pages.

ecoevo.social

Show threadDimitris KontopoulosAug 6
Overall, there is no single solution for thermal #adaptation of this #enzyme, which I think is super cool! Big thanks to my coauthors for helping make this #paper a reality, and I hope you like it! 🧵7/7
Show threadDimitris KontopoulosAug 6
In contrast, there was no systematic relationship between compactness and #temperature. The number and pattern of amino acid contacts also varied tremendously among adenylate kinases and not in a manner that strongly depended on temperature. 🧵6/7
Show threadDimitris KontopoulosAug 6
In other words, adenylate kinases from cold environments are more flexible than their hot-adapted counterparts at any given #temperature. But when the comparison is done at each species' respective native temperature, then the hot-adapted ones are more flexible! 🧵5/7
Show threadDimitris KontopoulosAug 6
Our results showed that there are many different paths towards #adaptation of adenylate kinases to extreme cold or extreme hot environments. In particular, the main pattern that we observed was an increase in structural flexibility with #temperature, both across #species and within. 🧵4/7
Show threadDimitris KontopoulosAug 6
By conducting several molecular dynamics simulations, we obtained estimates of flexibility and compactness at temperatures typically experienced by each #species and at non-native temperatures. We also compared the number and pattern of contacts formed among amino acids. 🧵3/7
Show threadDimitris KontopoulosAug 6
In this #paper, we looked at how the 3D #structure of an #enzyme may change through #adaptation to different thermal environments over millions of years. Specifically, we compared 70 adenylate kinases of #bacteria and #archaea, from extreme cold-loving #species to extreme heat-loving ones. 🧵2/7
Dimitris KontopoulosAug 6

I am excited to introduce our new @EvolLetters paper that has just come out:

https://academic.oup.com/evlett/advance-article/doi/10.1093/evlett/qraf026/8223096

🧵1/7

#temperature #adaptation #enzyme #microbes #ProteinStructure