Joanna MaselSep 6, 2024
Our latest paper https://elifesciences.org/articles/87335
directly measures the #EffectivePopulationSize that matters to #NearlyNeutralTheory / #DriftBarrier theory, as the degree to which #CodonBias differs from expectations from GC content. Surprisingly, stronger #NaturalSelection -> higher #IntrinsicStructuralDisorder proteins
#MolecularEvolution #PopulationGenetics #EvolgenPaper 1/
The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder

Proteins evolve more intrinsic structural disorder under more effective selection, with selection assessed via a novel metric of codon adaptation.

eLife
Joanna MaselMar 4, 2023
Our latest #preprint develops a new metric of #CodonAdaptation (not just #CodonBias) to measure the kind of #EffectivePopulationSize that matters to #NearlyNeutralTheory, and uses it to discover that #NaturalSelection prefers high #IntrinsicStructuralDisorder https://www.biorxiv.org/content/10.1101/2023.03.02.530449v1 1/6
#MolecularEvolution #PopulationGenetics #EvolgenPaper
Show threadJoanna MaselNov 4, 2022
We wanted to know what caused the extraordinarily #LongTermTrends we previously saw: in #IntrinsicStructuralDisorder and in the degree to which hydrophobic #AminoAcids are clustered, as a function of the time elapsed since a Pfam domain originated. https://elifesciences.org/articles/57347 2/11
Universal and taxon-specific trends in protein sequences as a function of age

Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.

eLife