Mastodawn

For #epithelial tissue homeostasis, cell elimination & proliferation must balance. @DaikiUmetsu &co show that faster cell removal is associated with switch from isolated to clustered #apoptosis, induced by ⬇️ #endocytosis & EGFR signaling #PLOSBiology https://plos.io/403rQ3Y

Reduction of endocytosis and EGFR signaling is associated with the switch from isolated to clustered apoptosis during epithelial tissue remodeling in Drosophila

Epithelial tissues undergo remodelling during development and to maintain homeostasis, and cell elimination rate must be coordinated with cell proliferation. This study shows that cell removal acceleration is associated with switching from isolated to clustered apoptosis, induced by the reduction of endocytosis and EGFR signalling.

WikiPathways Jul 4, 2024

Deregulation of miR‐1245b‐5p and miR‐92a‐3p and their potential target gene, GATA3, in epithelial–mesenchymal transition pathway in breast cancer. https://doi.org/10.1002/cnr2.1955 #BreastCancer #Epithelial‐MesenchymalTransition #Gata3 #Micrornas

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Jocelyn Etienne Mar 11, 2024

@preLights
And we also had a variant of your pathway C of #epithelial fold formation : folding by *tensile* mechanical #buckling

(Note: these are my hands on the photo, so technically this is my own's only and single published experiment!)

#epithelium

Scientific Frontline Feb 21, 2024

In children and adolescents, the #thymus gland functions as a "school for T cells". The organ in our chest is where the precursors of those T cells that would later attack the body's own cells are discarded. #Epithelial cells in the thymus present a large number of molecules that occur in the body to the future T cells.
#Biology #Medical #sflorg
https://www.sflorg.com/2024/02/bio02212402.html

Possible trigger for autoimmune diseases discovered

Immune system: B cells teach T cells which targets must not be attacked

JoramMooiweer Jan 27, 2024

We made a small #intestine-on-chip from cells isolated from urine!

It’s out: in our preprint we show the remarkable self-organization of #hiPSC-derived intestinal #epithelial, #mesenchymal and #neural cells in an intestine-on-chip system
https://www.biorxiv.org/content/10.1101/2024.01.04.574203v1

More info and tweetorial on X👇🏼
https://x.com/moerkensrenee/status/1750948722773557544?s=4646

PLOS Biology Jan 11, 2024

#Epithelial branching morphogenesis: @JakubSumbal @slvfre & @KoledovaZuzana use time-lapse imaging of #fibroblast co-cultures with epithelial #organoids to reveal that fibroblast contact & contractility are required for epithelial branching #PLOSBiology https://plos.io/48MaNog

Fibroblast-induced mammary epithelial branching depends on fibroblast contractility

Epithelial branching morphogenesis is an essential process in living organisms, creating organ-specific epithelial shapes. This study uses time-lapse imaging of fibroblast co-cultures with epithelial organoids or spheroids to reveal that fibroblast contact and contractility are required for epithelial branching.

Scientific Frontline Dec 24, 2023

Monash researchers have discovered a new way that #epithelial #cells, which form layers in #organs such as the skin and stomach, attach to one another, and how they perceive growth signals at these attachments, helping them form tissues of the right size and shape.
#Biology #Medical #sflorg
https://www.sflorg.com/2023/12/med12242301_01771117510.html

Monash researchers discover key to epithelial cell growth

The new study provides further insights into how Hippo signaling is coordinated in growing tissues.