Mastodawn

We made a small #intestine-on-chip from cells isolated from urine!

It’s out: in our preprint we show the remarkable self-organization of #hiPSC-derived intestinal #epithelial, #mesenchymal and #neural cells in an intestine-on-chip system
https://www.biorxiv.org/content/10.1101/2024.01.04.574203v1

Susanne Rafelski
is Deputy Director of Allen Institute for Cell Science
https://alleninstitute.org/person/susanne-rafelski/

"Integrated intracellular organization and its variations in human iPS cells"

How we can "know" a cell... observables:
molecular census (omics)
environment
organization
behavior

use #human #hiPSC as model

Susanne Rafelski, Ph.D. is the Deputy Director at the Allen Institute for Cell Science and was named to this position in December, 2020.

Allen Institute

Use Organoid to study Plasticity & Organotypic traits of #EndothelialCell

3D Cardiac Microtissue
#hiPSC-cardiomyocyte, -Fibroblast, -EC

scRNAseq
hiPSC-cardiac mesoderm-EC vs
hiPSC-Paraxial mesoderm-EC
in🫀Organoid

#hiPSC-RPE/EC/pericyte/fibroblast
PLGA nanoscaffold
Fibrin-gelatin

Modeling Dry & Wet #AMD🤠

RPE⏫Capillary Fenestration👈😎

A physiologically relevant 3D model of the outer-blood-retina-barrier recapitulates healthy and disease phenotypes.

Nature

Vascularization improves function performance of #hiPSC-β Islet #Organoid 🤠

Ca2+ as a surrogate for insulin secretion to high throughput screening