GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

Cambridge researchers develop light-driven reaction to efficiently modify drug molecules

📰 Original title: A lab mistake at Cambridge reveals a powerful new way to modify drug molecules

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

View full AI summary: https://killbait.com/en/cambridge-researchers-develop-light-driven-reaction-to-efficiently-modify-drug-molecules/?redirpost=d1fadd87-3bf9-4064-94f5-42d98bdf03a7

#science #chemistry #drugdevelopment #photochemistry

A very good read about computational chemistry and how it helps in drug discovery, and more importantly, what should be done so that it would be even more efficient.

https://medium.com/@dapscience/ai-drug-discovery-grand-challenges-benchmarks-be495dfb5ce4

#compchem #academicChatter #chemistry #medchem #drugDiscovery #drugDevelopment

China is no longer just a biotech market. It is increasingly a source of licensable innovation for global pharma.

Sanofi’s up-to-$1.53B rovadicitinib deal is the latest signal — and part of a much bigger shift in where drug innovation begins.

https://biotech.industryexaminer.com/sanofi-china-biotech-licensing-global-innovation/

#Biotech #Pharma #ChinaBiotech #DrugDevelopment #BiotechNews #TechNews

5 lessons from Vinay Prasad’s turbulent tenure at the FDA

Food and Drug Administration official Vinay Prasad self-destructed last week. The FDA announced Friday evening that he would…
#NewsBeep #News #Topstories #Biotechnology #drugdevelopment #FDA #Headlines #Pharmaceuticals #STAT+ #TopStories
https://www.newsbeep.com/425025/

This brief highlights a novel pharmacological advance with meaningful implications for the management of pediatric epilepsy, making it pertinent for mental health professionals who support children and families navigating chronic neurological conditions. The emphasis on seizure reduction and quality-of-life improvements informs considerations around functioning, daily routines, and caregiver stress, all central to comprehensive care provided by therapists, social workers, and mental health clinicians.

Article Title: New drug cuts seizures by up to 91% in children with rare epilepsy

Link to Science Daily Mind-Brain News: https://www dot sciencedaily dot com/releases/2026/03/260304184215 dot htm

#epilepsy #pediatrics #drugdevelopment #neuropsychology #qualityoflife

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