đ§ New paper by Chiu et al:
#SST #interneurons do not only suppress
#dendritic signaling. Via tonic activation of α5
#GABA receptors they can paradoxically enhance AP-evoked dendritic
#CalciumSignaling in
#cortical #pyramidal #neurons.
đ
https://doi.org/10.1016/j.neuron.2026.04.017
#Neuroscienceđ§ New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.
Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.
đ https://doi.org/10.1016/j.neuron.2026.04.017
#Neuroscience #CompNeuro
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Activation of Piezo 1 in the Pathogenesis of Glaucoma
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d13493824e179">Glaucoma is an eye disorder that damages the retinal ganglion cells and the optic
nerve, and can cause vision loss or blindness. However, a lack of understanding of
the underlying pathogenetic mechanisms has hampered the development of effective therapies.
The aim of this report was to investigate the potential role of Piezo 1 in glaucoma
development, by using a bead injection-based animal model of glaucoma. Piezo 1 expression
was not significantly altered by ocular hypertension in both whole eyeballs and the
retina in glaucomatous eyes. Moreover, no marked differences in ÎČ-actin expression
were observed between glaucomatous eyes and normal eyes. Nevertheless, enhanced expression
of Cofilin, a downstream target of the Yap/Piezo 1 signaling pathway, not only accelerated
depolymerization of F-actin to G-actin but also enhanced retinal cell calcium concentrations
in glaucomatous eyes. The development of glaucoma in bead-injected eyes was almost
completely abrogated by administration of the Piezo 1 inhibitor GsMTx-TFA. Together,
these results suggested that activation of Piezo 1 might be crucial for the initiation
of glaucomatous injury, by increasing calcium concentrations in retinal cells, leading
to up-regulation of Cofilin expression, accelerating depolymerization of F-actin to
G-actin, and ultimately disrupting the actin dynamic balance between G-actin and F-actin.
</p>
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Before you continue to YouTube
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Happy to share my new review: "From IP3RPEP6 inhibition of IP3 receptor
channels to insights: do channel subunits collaborate or cooperate?"
https://rdcu.be/ew0kv #calciumsignaling #ionchannelsFrom IP3RPEP6 Inhibition of IP3 receptor channels to insights: do channel subunits collaborate or cooperate?
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Fabrizio Musacchio
Fabrizio Musacchio
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