Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine
Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!
See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=2573
đđ 'Activation of Piezo 1 in the Pathogenesis of Glaucoma' - an article published in 'Neuropharmacology and Therapy' on #ScienceOpen đ https://www.scienceopen.com/hosted-document?doi=10.15212/npt-2024-0013
#GlaucomaResearch #Piezo1 #CalciumSignaling #Cofilin #ActinDynamics
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d13493824e179">Glaucoma is an eye disorder that damages the retinal ganglion cells and the optic nerve, and can cause vision loss or blindness. However, a lack of understanding of the underlying pathogenetic mechanisms has hampered the development of effective therapies. The aim of this report was to investigate the potential role of Piezo 1 in glaucoma development, by using a bead injection-based animal model of glaucoma. Piezo 1 expression was not significantly altered by ocular hypertension in both whole eyeballs and the retina in glaucomatous eyes. Moreover, no marked differences in β-actin expression were observed between glaucomatous eyes and normal eyes. Nevertheless, enhanced expression of Cofilin, a downstream target of the Yap/Piezo 1 signaling pathway, not only accelerated depolymerization of F-actin to G-actin but also enhanced retinal cell calcium concentrations in glaucomatous eyes. The development of glaucoma in bead-injected eyes was almost completely abrogated by administration of the Piezo 1 inhibitor GsMTx-TFA. Together, these results suggested that activation of Piezo 1 might be crucial for the initiation of glaucomatous injury, by increasing calcium concentrations in retinal cells, leading to up-regulation of Cofilin expression, accelerating depolymerization of F-actin to G-actin, and ultimately disrupting the actin dynamic balance between G-actin and F-actin. </p>
Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine
Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!
See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=1271
How Tiny Ion Channels Power Your Mind: A Deep Dive into Neuronal Function
#Neuroscience #BrainScience #Neurons #IonChannels #CalciumSignaling #NeuralCommunication #BrainHealth #Neurobiology #ElectricalSignals #Neuroplasticity
Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine
Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!
See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-colleg...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=12
From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival
#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine
Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine
Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!
See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97451
Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine
Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!
See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97346
Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine
Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!
See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97150
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