Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors - Lyu - British Journal of Pharmacology - Wiley Online Library https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70474?af=R

#IonChannels

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries - Donovan - British Journal of Pharmacology https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70492?af=R

#IonChannels

Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics

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P2X receptors are ATP-gated #IonChannels that are targets for treating #ChronicPain & #cough. The #cryoEM structure of the human #P2X3 receptor in complex with the negative allosteric modulator sivopixant reveals how it stabilizes inhibitory conformations of P2X3 @PLOSBiology https://plos.io/4vMWCvy
Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics

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Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

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⚡️ How does the Hv1 proton channel conduct protons faster than diffusion should allow?

🔗 Fluctuating hydrogen-bond network of the Hv1 ion channel. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.021

📚 CSBJ: https://www.csbj.org/

#Biophysics #ProtonChannel #MolecularDynamics #StructuralBiology #HydrogenBonding #IonChannels #ProtonTransport #Hv1

Deletion of the TRPV1 #Ionchannels attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure

https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP289721?af=R

Postdoctoral Research Fellow

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Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca2+ #ionchannels Open access.

https://www.tandfonline.com/doi/full/10.1080/19336950.2025.2556101