Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics

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⚑️ How does the Hv1 proton channel conduct protons faster than diffusion should allow?

πŸ”— Fluctuating hydrogen-bond network of the Hv1 ion channel. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.021

πŸ“š CSBJ: https://www.csbj.org/

#Biophysics #ProtonChannel #MolecularDynamics #StructuralBiology #HydrogenBonding #IonChannels #ProtonTransport #Hv1

Deletion of the TRPV1 #Ionchannels attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure

https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP289721?af=R

Postdoctoral Research Fellow

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Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca2+ #ionchannels Open access.

https://www.tandfonline.com/doi/full/10.1080/19336950.2025.2556101

Mouse retinal ganglion cells and night blindness |
TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells

J.General Physiol. https://rupress.org/jgp/article/157/6/e202413749/278375/A-mechanism-for-pathological-oscillations-in-mouse

Piezo1 #ionchannels regulate the mechanotransduction of soft matrix viscoelasticity | Nature Communications https://www.nature.com/articles/s41467-025-64185-5
Voltage-gated sodium #IonChannels: Mechanisms, disease, and a growing research community *Special Issue* Journal of General Physiology.
https://rupress.org/jgp/article/157/6/e202513878/278361/Voltage-gated-sodium-channels-Mechanisms-disease

Fatigue arising from KATP SUR2 gain-of-function in Cantu syndrome mice Scala -> Nichols. £€$Β₯

https://rupress.org/jgp/article/157/6/e202513781/278353/Muscle-fatigue-arising-intrinsically-from-SUR2-but

TLDR: Cantu syndrome -> muscle fatigue via overactive KATP #Ionchannels. Reversed by glibenclamide, suggesting possible new treatment.