찬호운동 없이도 뼈를 튼튼하게? 과학자들이 찾아낸 단백질의 비밀
홍콩대 연구진이 운동이 뼈를 강화하는 분자 메커니즘 Piezo1을 발견했다. 거동 불편자에게도 뼈 건강을 지킬 새 치료법 가능성이 열렸다.
ScienceOpen🔓📄 'Activation of Piezo 1 in the Pathogenesis of Glaucoma' - an article published in 'Neuropharmacology and Therapy' on #ScienceOpen 🔗 https://www.scienceopen.com/hosted-document?doi=10.15212/npt-2024-0013
#GlaucomaResearch #Piezo1 #CalciumSignaling #Cofilin #ActinDynamics
Activation of Piezo 1 in the Pathogenesis of Glaucoma
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d13493824e179">Glaucoma is an eye disorder that damages the retinal ganglion cells and the optic nerve, and can cause vision loss or blindness. However, a lack of understanding of the underlying pathogenetic mechanisms has hampered the development of effective therapies. The aim of this report was to investigate the potential role of Piezo 1 in glaucoma development, by using a bead injection-based animal model of glaucoma. Piezo 1 expression was not significantly altered by ocular hypertension in both whole eyeballs and the retina in glaucomatous eyes. Moreover, no marked differences in β-actin expression were observed between glaucomatous eyes and normal eyes. Nevertheless, enhanced expression of Cofilin, a downstream target of the Yap/Piezo 1 signaling pathway, not only accelerated depolymerization of F-actin to G-actin but also enhanced retinal cell calcium concentrations in glaucomatous eyes. The development of glaucoma in bead-injected eyes was almost completely abrogated by administration of the Piezo 1 inhibitor GsMTx-TFA. Together, these results suggested that activation of Piezo 1 might be crucial for the initiation of glaucomatous injury, by increasing calcium concentrations in retinal cells, leading to up-regulation of Cofilin expression, accelerating depolymerization of F-actin to G-actin, and ultimately disrupting the actin dynamic balance between G-actin and F-actin. </p>
CellBioNewsStudy shows #cells respond quickly to small #light-induced micro-environment #movements.
#sensing #calcium #gated_ion_channel #PIEZO1
https://phys.org/news/2024-01-cells-quickly-small-micro-environment.html
Study shows cells respond quickly to small light-induced micro-environment movements
Life sciences and photonics researchers at Tampere University have made a remarkable discovery in studying superficial cells' response to mechanical stimuli. By simulating the deformation of the extracellular matrix below the cells, researchers have shown that the cells quickly sense even minor changes in their environment, and their response is more complex than expected. The discovery may help to better understand, for example, the processes related to cancer metastasis formation.
PLOS BiologySpontaneous activity is an important attribute of neurodevelopment. @cssmity &co show that satellite #GlialCells in the #PNS display isolated spontaneous Ca2+ transients, sensitive to #mechanosensitive protein #Piezo1, revealing a role for #mechanobiology in the activity of developing neural cells #PLOSBiology https://plos.io/3t0Ko6w
Piezo1-mediated spontaneous calcium transients in satellite glia impact dorsal root ganglia development
Spontaneous activity is an important attribute of neurodevelopment. This study shows that satellite glial cells in the peripheral nervous system display isolated spontaneous Ca2+ transients that are specifically sensitive to the mechanosensitive protein Piezo1, revealing a role for mechanobiology in the activity of developing neural cells.