🧠 New paper by Pachitariu … @computingnature: spontaneous brainwide activity in mice shows macroscopic coordination that resembles linear dynamics driven by a critically normalized random symmetric matrix.

#Cortical and brainwide recordings showed power-law variance spectra, slow global activity modes, and little rotational structure, unlike #CA1, which looked closer to an efficient, less correlated code.

🌍 https://doi.org/10.1038/s41586-026-10528-1

#Neuroscience #CompNeuro #NeuralDynamics

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

RE: https://fediscience.org/@PLOSBiology/116579076475476559

🧠 Interesting new work on #cortical #PopulationCoding: Revah, Wolf, Gutnick & Neef show that the #encoding performance of cortical #neurons is not determined by single-cell properties alone, but by a combination of #dendrite size, #synaptic noise statistics, ion channels, and population size.

🧵1/2

🧠 New preprint by Garcia-Garcia et al.: The authors show that cerebellar #GranuleCells do not simply expand #cortical activity into a high-dimensional code. Instead, they preserve low-dimensional cortical #manifold geometry while reorienting it across contexts. This rotation separates similar tasks, reduces interference, and supports flexible dual-task learning.

📄 https://www.biorxiv.org/content/10.64898/2026.03.03.709240v1.full.pdf

#Neuroscience #NeuralDynamics #CompNeuro

#addestramento #cortical Cellule Cerebrali Addestrate a Giocare a Doom

https://www.notizie.buzz/articles/2026/03/02/cellule-cerebrali-addestrate-a-giocare-a-doom.html

https://youtu.be/lZ3_GUilpnk

https://www.cell.com/cell/fulltext/S0092-8674%2825%2901305-4

{December 05, 2025}
Open access
#Psilocybin triggers an activity-dependent #rewiring of large scale #cortical #networks

#virology #neuroimaging #bioengineering #TBI #breakthrough

「活體」伺服器：科學家培養「迷你人腦」為電腦提供動力

🧠 New study by Lempel et al. (2025): Visual experience after eye opening aligns #feedforward inputs (L4) and #RecurrentNetworks (L2/3) in mouse #VisualCortex. This improved alignment, together with enhanced orientation discrimination, creates coherent, reliable sensory codes, revealing how experience shapes stable #cortical representations:

🌍 https://doi.org/10.1016/j.neuron.2025.09.012

#Neuroscience #CompNeuro #Plasticity #CorticalCircuits