PShockettJan 21, 2023

A cool experiment on CD8 T cell proliferative expansion and memory.

Upon adoptive transfer (to a different mouse) "functionally competent T cells can retain the potential for extraordinary population expansion and longevity well beyond their organismal lifespan."
(at least 10 years!)

#Tcells #CD8Tcells #Tcellmemory #immunology #immuneresponse #celllongevity #cellproliferation

"Functional T cells are capable of supernumerary cell division and longevity"

https://www.nature.com/articles/s41586-022-05626-9?s=09

Functional T cells are capable of supernumerary cell division and longevity - Nature

Through iterative cycles of viral challenge and rechallenge over ten years, mouse T cells are demonstrated to have essentially infinite potential for population expansion and longevity without malignant transformation or loss of functional competence.

Nature
Thiago CarvalhoJan 12, 2023

'Long-lasting sepsis-induced immunoparalysis has been principally studied in primary (1°) memory CD8 T cells; however, the impact of sepsis on memory CD8 T cells with a history of repeated cognate Ag encounters is largely unknown but important in understanding the role of sepsis in shaping the pre-existing memory CD8 T cell compartment.'

#immunology #Sepsis #CTL #cd8tcells

https://journals.aai.org/jimmunol/article-abstract/210/2/168/237582/Inefficient-Recovery-of-Repeatedly-Stimulated?redirectedFrom=fulltext

Inefficient Recovery of Repeatedly Stimulated Memory CD8 T Cells after Polymicrobial Sepsis Induction Leads to Changes in Memory CD8 T Cell Pool Composition

Key Points. Susceptibility and loss of 1° and 4° memory CD8 T cells are similar after sepsis.Primary memory CD8 T cells become overrepresented over time in seps

American Association of Immunologists
Dr. Orna Izakson ND, RH(AHG)Dec 27, 2022

More science about Covid’s strategies for evading immune detection.

Preprint here: https://www.biorxiv.org/content/10.1101/2022.05.04.490614v3

#Covid #COVID19 #MHC #CD8TCells #InnateImmunity #Immune system

Dreamtraveler (Mary Ann)Nov 29, 2022
https://www.medrxiv.org/content/10.1101/2022.11.25.22282759v1
— Patients with severe #disease displayed persistent activation of #CD4plus and #CD8TCells #T_cells —
Elevated #plasma levels of IL-4, IL-7, IL-17 and TNF-α were present in #patients with severe — disease.
— persistent T-cell activation — #SevereCOVID-19 —Patients with severe disease reported a higher number of #LongCOVID symptoms which correlated with the frequency of two subsets of activated CD4+ and CD8+ T cells — #MaskUp
Seth Thomas ScanlonNov 18, 2022

In #Science (@sciencemagazine) this week, the Hanahan lab shows that the #RNA-binding protein #FMRP enables #tumors to evade being attacked by #CD8TCells. It does so by both suppressing #CCL17 & promoting #Tregs via #IL33 & #M2 #macrophages via #PROS1 & #ExtracellularVesicles!

https://bit.ly/Sci_abl7207

#CancerImmunology #RBP