Scientia2d ago
Evento on-line discute cooperação nacional e internacional na universidade
- cijnusp
https://jornal.usp.br/campus-ribeirao-preto/evento-on-line-discute-cooperacao-nacional-e-internacional-na-universidade/
#CampusRibeiroPreto #Eventos #EventosRibeiro #Universidade #Aucani #Cooperaointernacional #Cooperaonacional #FMRP #GrupodeEstudoCarreiraDocentedeImpacto #IEARP #Internacionalizao #USP
Evento on-line discute cooperação nacional e internacional na universidade

Promovida pelo Grupo de Estudo Carreira Docente de Impacto do IEA-RP, conferência terá como palestrante o ex-reitor da USP e atual presidente do Escritório Internacional da USP, Carlos Gilberto Carlotti Junior

Jornal da USP
ScientiaMar 26
Estudo busca voluntários para investigar impactos da nova Classificação Internacional de Doenças no Brasil
- cijnusp
https://jornal.usp.br/campus-ribeirao-preto/estudo-busca-voluntarios-para-investigar-impactos-da-nova-classificacao-internacional-de-doencas-no-brasil/
#CampusRibeiroPreto #CID11 #ClassificaoInternacionaldeDoenas #FMRP #GrupodeEstudosAvanadosemTecnologiaeInformaoemSadecomFocoemPopulaesVulnerveis #IEARP #MariaCristianeBarbosaGalvo
Estudo busca voluntários para investigar impactos da nova Classificação Internacional de Doenças no Brasil

Pesquisa é conduzida pela docente da FMRP Maria Cristiane Barbosa Galvão, que também coordena o Grupo de Estudos Confluencia, do IEA-RP

Jornal da USP
PLOS BiologyDec 6, 2023
This study shows that #RNAsplicing is widely dysregulated when #FMRP is lost; this involves multiple splicing factors, including MBNL1. In FMRP-depleted cells, Mbnl1 RNA is misspliced, mislocalizing #MBNL1, and in turn messing up further RNAs #PLOSBiology https://plos.io/3R6E9GN
FMRP deficiency leads to multifactorial dysregulation of splicing and mislocalization of MBNL1 to the cytoplasm

This study shows that RNA splicing is widely dysregulated in FMRP-deficient mouse tissues and cells and involves multiple splicing factors, including MBNL1. In FMRP-depleted cells, Mbnl1 RNA is mis-spliced, resulting in improper cytoplasmic localization of MBNL1, which in turn causes impairment of further RNAs.

Autism News InternationalFeb 17, 2023
Neurons struggle to spike without fragile X gene

https://www.spectrumnews.org/news/neurons-struggle-to-spike-without-fragile-x-gene/

#fragileXsyndrome #prefrontalcortex #dendrites #autism #cortex #News #FMR1 #FMRP
Neurons struggle to spike without fragile X gene | Spectrum | Autism Research News

FMR1 loss impairs sodium channels, hindering mouse neurons from generating the electrical signals needed to transmit information.

Spectrum | Autism Research News
PLOS BiologyJan 27, 2023
The RNA-binding protein #FMRP binds the Csw/SHP2 transcript, in turn regulating presynaptic MAPK/ERK signaling & #neurotransmission. This mechanistically links two cognitive disorders; #NoonanSyndrome & #FragileX syndrome #PLOSBiology https://plos.io/3JjpqG0
FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission

This study shows that the RNA-binding protein FMRP binds the Csw/SHP2 transcript, which in turn regulates presynaptic MAPK/ERK signaling and neurotransmission. This mechanistically links previously two previously unconnected cognitive disorders, Noonan syndrome and Fragile X syndrome.

PLOS BiologyJan 27, 2023
The RNA-binding protein #FMRP binds the Csw/SHP2 transcript, in turn regulating presynaptic MAPK/ERK signaling & #neurotransmission. This mechanistically links two cognitive disorders; #NoonanSyndrome & #FragileX syndrome #PLOSBiology https://plos.io/3JjpqG0
FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission

This study shows that the RNA-binding protein FMRP binds the Csw/SHP2 transcript, which in turn regulates presynaptic MAPK/ERK signaling and neurotransmission. This mechanistically links previously two previously unconnected cognitive disorders, Noonan syndrome and Fragile X syndrome.

PLOS BiologyJan 27, 2023
The RNA-binding protein #FMRP binds the Csw/SHP2 transcript, in turn regulating presynaptic MAPK/ERK signaling & #neurotransmission. This mechanistically links two cognitive disorders; #NoonanSyndrome & #FragileX syndrome #PLOSBiology https://plos.io/3JjpqG0
FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission

This study shows that the RNA-binding protein FMRP binds the Csw/SHP2 transcript, which in turn regulates presynaptic MAPK/ERK signaling and neurotransmission. This mechanistically links previously two previously unconnected cognitive disorders, Noonan syndrome and Fragile X syndrome.

Autism News InternationalJan 24, 2023
Missing mechanism helps solve fragile X protein mystery

https://www.spectrumnews.org/news/missing-mechanism-helps-solve-fragile-x-protein-mystery/

#intellectualdisability #repetitivebehaviors #socialdifficulties #fragileXsyndrome #neuralcircuits #connectivity #hippocampus #mousemodels #treatments #synapses #autism #News #FMR1 #FMRP
Missing mechanism helps solve fragile X protein mystery | Spectrum | Autism Research News

Cells from people with fragile X syndrome overproduce — but don’t accumulate — proteins. New work suggests that excessive protein breakdown may account for this discrepancy, and explain some of the syndrome’s traits.

Spectrum | Autism Research News
Seth Thomas ScanlonNov 18, 2022

In #Science (@sciencemagazine) this week, the Hanahan lab shows that the #RNA-binding protein #FMRP enables #tumors to evade being attacked by #CD8TCells. It does so by both suppressing #CCL17 & promoting #Tregs via #IL33 & #M2 #macrophages via #PROS1 & #ExtracellularVesicles!

https://bit.ly/Sci_abl7207

#CancerImmunology #RBP

Autism News InternationalSep 29, 2022
Fragile X neurons develop atypically in chimeric mice

https://www.spectrumnews.org/news/fragile-x-neurons-develop-atypically-in-chimeric-mice/

#fragileXsyndrome #mousemodels #autism #News #FMR1 #FMRP
Fragile X neurons develop atypically in chimeric mice | Spectrum | Autism Research News

After a brain transplant of reprogrammed human cells, the animals can for the first time recapitulate some neuronal changes seen in people with fragile X syndrome.

Spectrum | Autism Research News