𧬠Tumor Microenvironment β Jan 2026
β’ Engineered CAR-T and TAM targeting reshape local immunity
β’ Fibroblast checkpoints and macrophage signaling drive resistance
β’ DNA sensing and pyroptosis pathways amplify immunotherapy response
β’ Population-scale modeling refines immune stratification
#TumorMicroenvironment #CancerImmunology #Immunotherapy #TAMs #Biology
𧬠Tumor Microenvironment - Dec 2025
β’ Immune engineering boosts local antitumor activity
β’ Tumor immunity mapped at scale with population-level models
β’ Resistance linked to hypermutation, macrophages, and ECM remodeling
Research Technician Position - Sgourakis Laboratory
Children's Hospital of Philadelphia
See the full job description on jobRxiv: https://jobrxiv.org/job/childrens-hospital-of-philadelphia-27778-research-technician-position-sgourakis-laboratory/
#andProteinBiochemistry #Antibodydrugconjugates #biochemicalassays #cancerimmunology #cancerimmunotherapy #mhciantigenpr...
https://jobrxiv.org/job/childrens-hospital-of-philadelphia-27778-research-technician-position-sgourakis-laboratory/?fsp_sid=6969
Postdoctoral fellow in Cancer Epigenetics, Metabolism and Immunity
Roswell Park Comprehensive Cancer Center
See the full job description on jobRxiv: https://jobrxiv.org/job/roswell-park-comprehensive-cancer-center-27778-postdoctoral-fellow-in-cancer-epigenetics-metabolism-and-immunity/
#cancerimmunology #Cancermetabolism #epigenetics #Scienc...
https://jobrxiv.org/job/roswell-park-comprehensive-cancer-center-27778-postdoctoral-fellow-in-cancer-epigenetics-metabolism-and-immunity/?fsp_sid=6885
Postdoctoral fellow in Cancer Epigenetics, Metabolism and Immunity
Roswell Park Comprehensive Cancer Center
See the full job description on jobRxiv: https://jobrxiv.org/job/roswell-park-comprehensive-cancer-center-27778-postdoctoral-fellow-in-cancer-epigenetics-metabolism-and-immunity/
#cancerimmunology #Cancermetabolism #epigenetics #Scienc...
https://jobrxiv.org/job/roswell-park-comprehensive-cancer-center-27778-postdoctoral-fellow-in-cancer-epigenetics-metabolism-and-immunity/?fsp_sid=5772
Research Assistant in Systems Immunology & Cell Design
University of Pennsylvania
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-pennsylvania-27778-research-assistant-in-systems-immunology-cell-design/
#Autoimmunity #bioengineering #cancerimmunology #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-pennsylvania-27778-research-assistant-in-systems-immunology-cell-design/?fsp_sid=3693
Research Assistant in Systems Immunology & Cell Design
University of Pennsylvania
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-pennsylvania-27778-research-assistant-in-systems-immunology-cell-design/
#Autoimmunity #bioengineering #cancerimmunology #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-pennsylvania-27778-research-assistant-in-systems-immunology-cell-design/?fsp_sid=3287
PhD in Immunotherapy & 3D Tumor Models β IMol, Polish Academy of Sciences
The International Institute of Molecular Mechanisms
See the full job description on jobRxiv: https://jobrxiv.org/job/the-international-institute-of-molecular-mechanisms-27778-phd-in-cancer-immunotherapy-3d-tumor-models/
#3dtumormodels #cancerimmunology #tumormicroenvironment #Sci...
https://jobrxiv.org/job/the-international-institute-of-molecular-mechanisms-27778-phd-in-cancer-immunotherapy-3d-tumor-models/?fsp_sid=2895
PhD in Immunotherapy & 3D Tumor Models β IMol, Polish Academy of Sciences
The International Institute of Molecular Mechanisms
See the full job description on jobRxiv: https://jobrxiv.org/job/the-international-institute-of-molecular-mechanisms-27778-phd-in-cancer-immunotherapy-3d-tumor-models/
#3dtumormodels #cancerimmunology #tumormicroenvironment #Sci...
https://jobrxiv.org/job/the-international-institute-of-molecular-mechanisms-27778-phd-in-cancer-immunotherapy-3d-tumor-models/?fsp_sid=1075
'Single-cell sequencing reveals the expansion and diversity of T cell subsets in the bone marrow microenvironment of chronic myeloid leukemia' - a Genes & Diseases article on #ScienceOpen:
π https://www.scienceopen.com/document?vid=a1a783a1-5180-487b-b736-d5d814a5fb75
#CancerImmunology #LeukemiaResearch #TCells #SingleCellSequencing
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d9200406e246">The immune microenvironment plays an important role in leukemia treatment. However, a specific single-cell profiling of the immune alteration in bone marrow of chronic myeloid leukemia (CML) patients is still lacking. We performed multi-level single-cell sequencing to systematically decipher the bone marrow T cell atlas of CML patients. The results exhibited extensive changes of T cells, including the decreased CD4 T cells and increased CD8 T cells in the CML bone marrow. Subpopulation analysis revealed a significant increase of CD8 terminal effector (TE) cells and a significant decrease of CD4 naΓ―ve T cells. T cell receptor sequencing showed that the overall diversity of the T cell receptor repertoire was reduced in CML, with the exception of the CD8 TE cell. In addition, CD8 TE cells were the main source of gene expression differences in CD8 T cells. Intercellular communication analysis revealed the altered interaction between CD8 TE and other non-T cells in CML, including neutrophil subtype, indicating the potential regulation of bone marrow microenvironment cells on CD8 TE dynamics. Collectively, our work characterises the alteration of T cell subsets in CML patients at multiple single-cell levels, providing a valuable resource for understanding the immune microenvironment and developing new immune strategies for CML therapy. </p>
Summarized Science
jobRxiv
ScienceOpen