🫧 Extracellular Vesicles - Apr 2026
• HCC-derived EVs promote lung metastasis via ITGα24 signaling
• 5-HIAA from EVs remodels vasculature to enable leptomeningeal metastasis
• Senescent hepatocyte EVs enhance metastasis via miRNA release
• Lemon-derived EV capsules boost colorectal cancer chemotherapy
🫧 Extracellular Vesicles - Mar 2026
• Immune cells regulate adipocyte EV levels, impacting metabolic health
• Novel EV detection method achieves high sensitivity in cancer diagnosis
• EV dynamics may serve as biomarkers for cognitive decline
• CAV1-DOT1L axis in TAM-derived EVs promotes vasculogenic mimicry in PDAC
🫧 Extracellular Vesicles - Feb 2026
• NE+ EVs drive chronic inflammation and emphysema in COPD
• LipoFB-derived EVs restore lung cell function in COPD
• TIGIT in myeloid cells linked to immunosuppression in glioblastoma
• Mitochondrial transfer via EVs boosts glioblastoma resistance
• RORγ-enriched exosomes alleviate diabetic kidney injury
• EVs play key roles in metabolic regulation and disease
🧬 Extracellular Vesicles — Jan 2026
• Inhalable and engineered EVs overcome immunotherapy resistance
• EV-derived miRNAs reprogram macrophage phenotypes in cancer
• Regenerative applications expand in cardiac, cartilage, and tendon repair
Extracellular Vesicles - Dec 2025 🧪
• Vesicle signaling linked to cancer progression and therapy resistance
• Exosome liquid biopsies show high accuracy for early cancer detection
• EVs mediate mitochondrial quality control and tissue protection
• Hybrid vesicles enhance oral antibiotic absorption and mitigate gut dysbiosis
• Engineered vesicles improve drug delivery
📄 'Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer' - a DrugRxiv #Preprint on #ScienceOpen:
➡️ https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/DRUGARXIV.PR000030.v1
#REPO4EU #DrugRepurposing #AnaplasticThyroidCancer #ExtracellularVesicles #Vandetanib #LiquidBiopsy
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d660062e280"> <b>Background: </b>Anaplastic thyroid cancer (ATC) is an aggressive and rare disease. Rapid metastasis and limited treatments call for additional therapeutic options, including drug repurposing. The early spreading of ATC highlights the importance of rapid therapy success assessment, which could be achieved by measurement of extracellular vesicle (EV)-associated cell-free RNA in liquid biopsy samples. Recent studies have discovered the potential of the receptor tyrosine kinase inhibitor vandetanib for ATC treatment <i>in vitro</i> and <i>in vivo</i>. Given the rarity of ATC patients receiving off-label vandetanib treatment, acquiring patient samples for clinical studies is a prolonged process, and pre-clinical investigations are needed to elucidate the effects of vandetanib on ATC cells. </p><p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d660062e291"> <b>Objective:</b> Here, we present an <i>in vitro</i> study addressing holistic transcriptional and proteomic changes induced in the ATC cell line Cal62 by three doses of vandetanib and quantified by high-throughput methods. </p><p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d660062e299"> <b>Methods:</b> By comparing the transcriptional and proteomic data sets and applying dimensional reduction models such as sparse partial least-squares discriminant analysis, we refined a set of 21 biomarker candidates. </p><p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d660062e304"> <b>Results:</b> Out of these, we report a final signature of eight transcriptional biomarkers, validated in cellular and cell-free RNA by RT-qPCR and verified for biological significance and discriminatory power by pathway over-representation analysis and partial least-squares regression. This transcriptional biomarker signature can distinguish vandetanib treatment from control in cell-free RNA isolated from Cal62 EVs and can be measured reliably, easily, and quickly using RT-qPCR. </p><p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d660062e309"> <b>Conclusions:</b> Our findings may serve as a basis for future clinical trials with liquid biopsy samples from ATC patients undergoing off-label vandetanib treatment. </p>
Exosomes in Medicine: Unlocking New Therapeutic Frontiers
Exosomes are nano-sized vesicles that originate from multivesicular bodies and serve as messengers between cells. They play crucial roles in immune modulation, neurodegenerative diseases, and regenerative medicine.
Exosomes- https://articlescad.com/exosomes-tiny-messengers-with-big-potential-136371.html
#CoherentMarketInsights #ExtracellularVesicles #CellCommunication #RegenerativeMedicine #Nanomedicine
Postdoctoral Fellow on Neuroimmunology and Blood-brain communication
UAB School of Medicine
Join us as a #Neuroimmunoloy #ExtracellularVesicles postdoc. UAB Kano Lab is looking for a motivated postdoc candidate.
See the full job description on jobRxiv: https://jobrxiv.org/job/uab-school-of-medicine-27778-postdoctoral-fellow-on-neuroimmunology-and-blood-...
https://jobrxiv.org/job/uab-school-of-medicine-27778-postdoctoral-fellow-on-neuroimmunology-and-blood-brain-communication/?feed_id=88946
Apoptotic cells are known to signal to neighboring cells to stimulate proliferation and compensate for cell loss, but how? This study shows that apoptotic extracellular vesicles carrying MIF directly stimulate epithelial stem cell repopulation during tissue maintenance, and guide macrophages to induce localized proliferation.
Postdoctoral Fellow on Neuroimmunology and Blood-brain communication
UAB School of Medicine
Join us as a #Neuroimmunoloy #ExtracellularVesicles postdoc. UAB Kano Lab is looking for a motivated postdoc candidate.
See the full job description on jobRxiv: https://jobrxiv.org/job/uab-school-of-medicine-27778-postdoctoral-fellow-on-neuroimmunology-and-blood-...
https://jobrxiv.org/job/uab-school-of-medicine-27778-postdoctoral-fellow-on-neuroimmunology-and-blood-brain-communication/?feed_id=85231
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