PShockettA cool experiment on CD8 T cell proliferative expansion and memory.
Upon adoptive transfer (to a different mouse) "functionally competent T cells can retain the potential for extraordinary population expansion and longevity well beyond their organismal lifespan."
(at least 10 years!)
#Tcells #CD8Tcells #Tcellmemory #immunology #immuneresponse #celllongevity #cellproliferation
"Functional T cells are capable of supernumerary cell division and longevity"
Functional T cells are capable of supernumerary cell division and longevity - Nature
Through iterative cycles of viral challenge and rechallenge over ten years, mouse T cells are demonstrated to have essentially infinite potential for population expansion and longevity without malignant transformation or loss of functional competence.