Thiago Carvalho"Here, we have identified the mTOR pathway as a major determinant of chemosensitivity through a genome-wide CRISPR knockout screen. We show that mTOR inhibition causally leads to the emergence of a reversible drug-tolerant persister population with a senescence phenotype, which is dependent on autophagy and G2/M cell cycle arrest for survival."
mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resistant persisters - Nature Communications
Chemotherapy resistance poses a major obstacle in cancer therapy. Here, the authors identify the mTOR pathway as a determinant of chemosensitivity and demonstrate that inhibition of mTOR promotes the persistence of a chemotherapy-resistant cancer-cell subpopulation.
Carl T. Bergstrom
Christophe Leterrier π¬
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eLife
Jess Wade
Tatiana Moiseeva
Michael Love