Guts within guts: the roundworm A. suum microbiome is derived but distinct from the host m

Intestinal roundworms infect multitudes of humans and animals globally. While these worms are parasitic eukaryotic members of the host’s microbiome, they also contain their own gut microbiome. But there is currently almost no data on the microbiomes of these prevalent parasites. So, to narrow this gap, researchers recently examined the microbiomes of Ascaris suum and their pig hosts . In the section of the intestine where they reside, the jejunum, the worms were associated with reduced host microbiome diversity . Further, the A. suum microbiome contained bacterial taxa derived from the host microbiome, but was less diverse and had its own signature . suggesting that the Ascaris intestine supported the growth of low abundance microbes from the host gut . While this is just one parasite-host pairing and more research is needed, these results suggest that A. suum impacts the host’s microbiome. and that the Ascaris gut is a selective niche harboring bacteria derived from the host’s gut . Understanding these parasite-microbiome interactions could lead to new disease prediction and parasite control tools . Midha et al.

proGenomes3: approaching one million accurately and consistently annotated high-quality prokaryotic genomes

Abstract. The interpretation of genomic, transcriptomic and other microbial ‘omics data is highly dependent on the availability of well-annotated genomes. As th

Molecular Microbiology: Biochemistry to Disease

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A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings - Nature Microbiology

Genomic analyses of Klebsiella isolates sampled from multiple human, animal and environmental sources in Northern Italy explore Klebsiella population diversity and show that transmission of multidrug-resistant clones between clinical and environmental settings is scarce.

Hypermutator strains of Pseudomonas aeruginosa reveal novel pathways of resistance to combinations of cephalosporin antibiotics and beta-lactamase inhibitors

Hypermutation can accelerate the development of antibiotic resistance in bacteria, but are the mechanisms the same in hypermutator strains as in wild-type cells? This study shows that mismatch repair-deficient Pseudomonas aeruginosa can evolve novel mechanisms of resistance to two last-line, broad spectrum antibiotics, characterizing one such mechanism involving mutations in the chromosomal RND efflux pump, MexVW.