Kerry J. Laing, PhD

@[email protected]
106 Followers
202 Following
28 Posts
Immunologist, delving deep into the epitope landscape and functional characteristics of virus-specific T cells. 
First Gen. Scottish-born scientist living in Seattle. The one standing in the corner too shy to make the first move. #Tcells #Immunology #FirstGen #WomenInStem #ArmyBrat

My bibliographyhttps://www.ncbi.nlm.nih.gov/myncbi/kerry.laing.1/bibliography/public/
Kerry J. Laing, PhDJan 3, 2024
New manuscript 📃: immune responses to SARS-CoV-2 mRNA vaccines after primary vaccination with Novavax NVX-cov2373 are pretty solid. Challenging study to do in an ever-changing climate. Congrats to primary author Dr. Tia Babu. https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad673/7505602?login=true
SARS-CoV-2 Omicron sub-variant Neutralization following a primary vaccine series of NVX-CoV2373 and BNT162b2 monovalent booster vaccine

Abstract. We evaluated the immunologic response to a novel vaccine regimen that included two doses of NVX-CoV2373 (Novavax) followed by 1 dose of BNT162b2 (Pfiz

OUP Academic
Kerry J. Laing, PhDJan 3, 2024
An editorial of our paper sure takes the sting out of the grueling review process. https://www.nature.com/articles/s41590-023-01695-8
Activation-based repertoire analysis for T cell clonal dynamics in hybrid COVID-19 immunity - Nature Immunology

The use of T cell receptor signatures to track activated spike-specific T cell dynamics between recovery from SARS-CoV-2 infection and subsequent mRNA vaccination shows that vaccination effectively recruits pre-existing memory and new CD8+ T cell clonotypes.

Nature
Show threadKerry J. Laing, PhDDec 7, 2023
Available on readcube: https://rdcu.be/dsTTJ
Kerry J. Laing, PhDDec 6, 2023

New publication! Kudos to the primary authors for their patience and stamina thru a long review process to get this over the finish line. Full TCR sequencing and lab analyses support CD8 T cells dominate vaccine responses in SARS-CoV-2 hybrid immunity. #COVID, #SARSCoV2, #TCELLS #hybridimmunity

https://t.co/LUzRz6Jz3D

Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19 - Nature Immunology

Koelle and colleagues use an activation marker-dependent approach to determine the recruitment of TCR by three doses of mRNA vaccination in individuals previously infected with SARS-CoV-2.

Nature
Kerry J. Laing, PhDDec 2, 2023

Why are some vaccines more protective than others? Our manuscript investigating T cell characteristics in persons that received different zoster vaccination formulations is officially out!

https://www.jci.org/articles/view/172634

We are deeply honored that Prof. Tony Cunningham has chosen to highlight this in his insightful commentary. #shingles #vaccine #Tcells

https://jci.org/articles/view/175378

JCI - Recruitment of naive CD4+ T cells by the recombinant zoster vaccine correlates with persistent immunity

Kerry J. Laing, PhDOct 4, 2023
Coming soon: Our paper in collaboration with Adriana Weinberg's UCD team, which compares initial memory subset and longevity of CD4 T cells recruited by different shingles vaccines. Reaching into naive populations may explain long-lived responses. https://www.jci.org/articles/view/172634
JCI - Recruitment of naive CD4+ T cells by the recombinant zoster vaccine correlates with persistent immunity

Kerry J. Laing, PhDFeb 14, 2023
#immunology folks—we are hunting for #cloned #HLA cDNAs and coming up empty for HLA-A*66:01. Does anyone know a source to acquire this before we burn hours to isolate/clone it ourselves or spend $$$ to have it synthesized?
Show threadKerry J. Laing, PhDJan 30, 2023
UPDATE: it’s put back together like a 3D puzzle, albeit with mysteriously missing case screws. Onward to calibration!
Kerry J. Laing, PhDJan 30, 2023
Lab scientists! We need your help. our Rainin LTS multichannel pipette was discovered on the floor in pieces today. Anyone know how to reassemble? I can find no instruction online 😔
Kerry J. Laing, PhDJan 5, 2023
Ram Lab UWJan 4, 2023

Solomon and Kazushige show a novel mechanism of T regulatory cell-mediated suppression of CD4 activation through the inhibition of mRNAs encoding protein synthesis machinery. Here we show T regulatory cells shape effector T cell translatome. This is a result of a fantastic collaboration with Steve Ziegler's lab. We thank all the co-authors who contributed to this work. #RNA #Tregs #Tolerance #Autoimmunity

https://rupress.org/jem/article/220/3/e20221676/213791/Regulatory-T-cells-suppress-CD4-effector-T-cell

Regulatory T cells suppress CD4+ effector T cell activation by controlling protein synthesis

We show suppression of CD4 effector T cell activation by Tregs is enforced through active mRNA translational control of the protein synthesis machinery. We show

Rockefeller University Press