Solomon and Kazushige show a novel mechanism of T regulatory cell-mediated suppression of CD4 activation through the inhibition of mRNAs encoding protein synthesis machinery. Here we show T regulatory cells shape effector T cell translatome. This is a result of a fantastic collaboration with Steve Ziegler's lab. We thank all the co-authors who contributed to this work. #RNA #Tregs #Tolerance #Autoimmunity

https://rupress.org/jem/article/220/3/e20221676/213791/Regulatory-T-cells-suppress-CD4-effector-T-cell

Regulatory T cells suppress CD4+ effector T cell activation by controlling protein synthesis

We show suppression of CD4 effector T cell activation by Tregs is enforced through active mRNA translational control of the protein synthesis machinery. We show

Rockefeller University Press
Finally some clarity on the mechanistic basis of T reg mediated suppression- repression of the translation machinery!! How cool!!! Congrats @RamLab, Ziegler lab and colleagues on this amazing work! 🎉🥳