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https://www.sciencedaily.com/releases/2026/01/260103155034.htm

Type 2 diabetes physically changes the human heart, study finds
Type 2 diabetes doesn’t just raise the risk of heart disease—it physically reshapes the heart itself. Researchers studying donated human hearts found that diabetes disrupts how heart cells produce energy, weakens the muscle’s structure, and triggers a buildup of stiff, fibrous tissue that makes it harder for the heart to pump. These changes are especially severe in people with ischemic heart disease, the most common cause of heart failure.









But, exerkines describe the circulating factors produced and secreted by any tissue or organ that are released in response to repeated bouts of exercise.