After 60+ years, the common diabetes drug metformin has been found to unexpectedly affect the brain.
A new study shows it targets the protein Rap1 in the ventromedial hypothalamus, activating SF1 neurons to help lower blood glucose — and it works at much lower concentrations in the brain than in the body.
Promising findings that could lead to better treatments for glucose control and possibly brain protection.

#Metformin #Diabetes #BrainHealth #MedicalResearch #Prediabetes

https://www.sciencealert.com/after-60-years-diabetes-drug-revealed-to-unexpectedly-affect-the-brain

This brief note highlights a discovery about metformin influencing brain processes, not solely peripheral metabolic functions. For mental health professionals, the finding implies a potential link between pharmacological interventions for metabolic conditions and central nervous system pathways, which may inform considerations about holistic patient care and comorbidity management in mood and cognitive health.

Article Title: Metformin’s hidden brain pathway revealed after 60 years

Link to Science Daily Mind-Brain News: https://www dot sciencedaily dot com/releases/2026/03/260325055441 dot htm

Metformin’s hidden brain pathway revealed after 60 years
https://www dot sciencedaily dot com/releases/2026/03/260325055441 dot htm
A major discovery reveals that metformin works not just in the body, but in the brain. By switching off a key protein and activating specific neurons, the drug lowers blood sugar through a previously hidden pathway, opening new doors for diabetes treatment.
via Mind & Brain News -- ScienceDaily https://www dot sciencedaily dot com/news/mind_brain/
March 25, 2026 at 06:47AM

#diabetes #metformin #neuroscience #brainpathways #mentalhealthconnections

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THREAT MODEL: COVID 🦠
for Mar. 12th, 2026
by independent journalist @violetblue

- #USmilitary study concludes 42% of #Covid infections lead to #LongCovid "regardless of initial disease severity”

- RFK’s #MAHA Institute calls to eliminate all childhood vaccines

- A new Long Covid treatment guide

- Babies with Covid “develop more serious disease than those with RSV”

- Trump admin removes more Covid datasets

- #Aotearoa #NewZealand ’s new Covid report smothered by disinformation

- #AotearoaNZ vaccinologist: repeat infection is “accumulating damage”

- Study: #Metformin reduces Long Covid risk but not an effective LC treatment

- US survey: only 26 of 400 Long Covid clinics remain

...and much more.

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https://www.patreon.com/posts/covid-march-12-152830056

#ThreatModel #ThreatModelCovid #ThreatModelNewsletters #VioletBlue #COVIDnews #PublicHealth #CovidIsNotOver

#BerberineSupplements: Is the “Natural #Metformin” Living Up to the Hype?

In the ever-evolving world of #metabolichealth, few #supplements have captured the public’s imagination like berberine.

https://www.dietofcommonsense.com/berberine-supplements-natural-metformin/

𝙏𝙝𝙧𝙚𝙖𝙩 𝙈𝙤𝙙𝙚𝙡: 𝘾𝙤𝙫𝙞𝙙
𝘧𝘰𝘳 Feb. 5th, 2026
𝘣𝘺 𝘫𝘰𝘶𝘳𝘯𝘢𝘭𝘪𝘴𝘵 @violetblue

- Trends suggest US is in for a second #Covid surge

- First vaccine targeting #SARS virus family enters human trials

- Even more evidence showing #metformin prevents #LongCovid

- Australian #WinterOlympics team staff test positive for Covid ahead of #WinterOlympics2026 Milano Cortina Games

- Four #EU orgs form international federation Long COVID Rise Up

- Largest pediatric Long Covid trial to launch this year

- Many older US adults haven’t had recent flu or Covid vaccine

- Large study finds Covid shots don’t affect fertility (but catching Covid does)

- New study: Covid in pregnancy linked w/risk of childhood neurodevelopmental disorders

...and much more.

* 𝙏𝙝𝙧𝙚𝙖𝙩 𝙈𝙤𝙙𝙚𝙡 𝘪𝘴 𝘧𝘳𝘦𝘦 𝘵𝘰 𝘳𝘦𝘢𝘥 -- 𝘱𝘭𝘦𝘢𝘴𝘦 𝘩𝘦𝘭𝘱 𝘬𝘦𝘦𝘱 𝘪𝘵 𝘢𝘤𝘤𝘦𝘴𝘴𝘪𝘣𝘭𝘦 𝘵𝘰 𝘢𝘭𝘭 𝘣𝘺 𝘣𝘦𝘤𝘰𝘮𝘪𝘯𝘨 𝘢 𝘱𝘢𝘵𝘳𝘰𝘯, 𝘦𝘷𝘦𝘯 $1/𝘮𝘰𝘯𝘵𝘩 𝘮𝘢𝘬𝘦𝘴 𝘢 𝘥𝘪𝘧𝘧𝘦𝘳𝘦𝘯𝘤𝘦 *

https://www.patreon.com/posts/covid-february-5-149973355

#ThreatModel #ThreatModelCovid #ThreatModelNewsletters #VioletBlue #COVIDnews #PublicHealth #CovidIsNotOver

I guess there was a study that claimed Metformin wasn’t helpful with covid in people who are not obese. This looks like a good rebuttal with some valid points about why the study wasn’t so good.

“Metformin Therapy for Patients With COVID-19 Without Obesity”
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2842942

#metformin #JAMA #covid #LongCovid

#LabPlot at the service of #researchers.  

@[email protected]

It's rewarding to us to know that #LabPlot was used for the #drug release #kinetics investigation in this recent study on niosomal co-delivery of #metformin and #telaglenastat.

➡️ https://www.sciencedirect.com/science/article/pii/S0753332225010376

#Research #Science #OpenSource #FreeSoftware #FOSS #KDE #FreeOriginProAlternative #BreastCancer #Cancer #Cytotoxicity