Max Lab UW SeattleAug 15, 2025

Hantao Wang will defend his PhD dissertation on Tues 8/19 (10 am PDT), open to all via Zoom!

"Examining Cortical and Subcortical Processes Underlying Speech Auditory-motor Adaptation and Syllable Sequence Learning"

https://washington.zoom.us/j/94491363101?pwd=NGjWWgAy9SjuVM8eKCbPmeiDvxGiI2.1

#Speech #MotorControl #Parkinsons #EssentialTremor #DBS #Subcortical #Adaptation

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PLOS BiologyOct 22, 2024
Thinking of #music... @dariquima &co show that mental manipulation of a melody systematically changes its neural representation in #auditory, association, #sensorimotor & #subcortical areas, reflecting volitional control of auditory images #PLOSBiology https://plos.io/3NBg7lV
Decoding reveals the neural representation of perceived and imagined musical sounds

How does the brain process musical thoughts? This study shows that the mental manipulation of a melody systematically changes its neural representation in auditory, association, sensorimotor and subcortical areas, reflecting volitional control of auditory images.

Tim VineyJun 8, 2023
***New preprint alert***
"Pathway-specific progression of Tau pathology in the human thalamus"
We discovered that large presynaptic terminals containing vGLUT2 preferentially accumulate paired helical filaments of #Tau in the anterodorsal nucleus of the #thalamus, even at the stage before #Alzheimer’s disease.
But we could not detect them in the small corticothalamic terminals, suggesting Tau is not spreading anterogradely from the #cortex.
We also detected pathological Tau in both presynaptic and postsynaptic sites, which suggests Tau crosses specific #synapses.
Adjacent thalamic nuclei such as the anteroventral and mediodorsal were relatively resistant to Tau #pathology.
We suggest there is a 'hidden' #subcortical route for the spread of Tau in the ageing human #brain.
Since the anterodorsal thalamic nucleus is so vulnerable, and contains high densities of #neurons that are sensitive to head direction and gravity, it may explain the very early deficits in spatial orientation in people that go on to develop Alzheimer’s disease.
Please see our #preprint for further details:
https://www.biorxiv.org/content/10.1101/2023.06.05.543738v1
PLOS BiologyNov 30, 2022
Higher-order sensory #ThalamicNuclei are densely connected with multiple #cortical & #subcortical areas, but what do they do? During active sensing, the POm integrates information from the #cortex & plays a key role in #SensoryPerception #PLOSBiology https://plos.io/3XFqbhx
Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination

Higher-order sensory thalamic nuclei are densely connected with multiple cortical and subcortical areas, but their role remains elusive. This study shows that during active sensing, the posteromedial thalamic nucleus (POm) integrates information from the cortex and plays a significant role in sensory perception.

PLOS BiologyNov 29, 2022
Higher-order sensory #ThalamicNuclei are densely connected with multiple #cortical & #subcortical areas, but what do they do? During active sensing, the POm integrates information from the #cortex & plays a key role in #SensoryPerception #PLOSBiology https://plos.io/3XFqbhx
Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination

Higher-order sensory thalamic nuclei are densely connected with multiple cortical and subcortical areas, but their role remains elusive. This study shows that during active sensing, the posteromedial thalamic nucleus (POm) integrates information from the cortex and plays a significant role in sensory perception.

PLOS BiologyNov 29, 2022
Higher-order sensory #ThalamicNuclei are densely connected with multiple #cortical & #subcortical areas, but what do they do? During active sensing, the POm integrates information from the #cortex & plays a key role in #SensoryPerception #PLOSBiology https://plos.io/3XFqbhx
Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination

Higher-order sensory thalamic nuclei are densely connected with multiple cortical and subcortical areas, but their role remains elusive. This study shows that during active sensing, the posteromedial thalamic nucleus (POm) integrates information from the cortex and plays a significant role in sensory perception.

Kevin SitekNov 14, 2022

Hello! Server change, so here's my re-introduction 👋

I'm a research scientist at the University of Pittsburgh studying #subcortical contributions to human #auditory processing and communication 🗣️ 👂 🧠

Really happy to see this place take off—excited to use it to keep building a fairer, more vibrant scientific community!

Fred M StollNov 10, 2022

Overdue #introduction #1stToot

Hi 👋🏼! I’m a #neuroscience Instructor in Rudebeck’s lab at #MountSinai NY.

Strong focus on animal #learning #DecisionMaking #Reward #valuation and how #prefrontal #subcortical regions represent these and interact at the level of #neurons and #LFP.

Proponent of recording neurons in too many areas simultaneously, and a #Matlab enthusiast (I know.. I complain about it too!).

Off lab, you will find me #biking , pushing a #stroller , and/or enjoying #beers.