The medial geniculate body #MGB in the #auditory #thalamus is a key early node in sound processing. @neimarkgeffen @labhaas &co show in mice that two inhibitory neuron types have distinct connectivity & effects on sound processing @PLOSBiology https://plos.io/47twOtM
Thalamic reticular neurons provide cell type-specific modulation of sound processing in the auditory thalamus

The thalamic reticular nucleus is an important regulator of sensory processing and computation, but the functional roles of distinct neuron types in this brain region are unknown. By examining responses to tones in mice, this study shows that the two key inhibitory neuron types of the thalamic reticular nucleus exert unexpected, bidirectional effects on sound processing in the auditory thalamus.

A study analyzes postmortem human brain tissue to identify brain regions involved in bipolar disorder. Using single-nucleus RNA sequencing, researchers found a substantial loss of excitatory neurons in the paraventricular thalamic nucleus and altered gene activity, suggesting this deep brain structure as a key site in BD pathology. The findings point toward new directions for diagnosis and treatment, while noting limitations such as small sample size and medication effects.

This work is of interest to psychology enthusiasts because it highlights a subcortical brain region involved in emotion regulation and the molecular changes that may underlie bipolar disorder. It also demonstrates how advanced methods like single-cell analysis can illuminate cellular-level changes associated with psychiatric conditions.

Article Title: Scientists identify key brain structure linked to bipolar pathology

Link to PsyPost Article: ift dot tt/t1yi5Gs

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#bipolardisorder #paraventricularthalamicnucleus #thalamus #singlecellRNAseq #neuroscience

How the brain decides what to remember

Memories are initially formed in the hippocampus, but the thalamus is a key next step in the relay that is important for selecting and routing memories for longer term storage. Sequentially operating molecular "timers" spanning the hippocampus, thalamus, and cortex, keep memories alive for progressively longer timespans. Adjusting these timing mechanisms could lead to recovery of memory function by helping the brain work around damaged areas.

EurekAlert!

Always on the go? Need a quick pick-me-up?

TAKE A BREAK!

Welcome to Basingstoke - out now on PS5!

http://thalamus.link/zombies

#basingstoke #welcometobasingstoke #playstation5 #ps5 #indiegames #indiedev #thalamusdigital #thalamus #puppygames

Heads-up! We'll be live-streaming Welcome to Basingstoke over on our Twitch channel today at 5pm GMT / 9am PDT!

twitch.tv/thalamusdigital/

#basingstoke #welcometobasingstoke #playstation5 #ps5 #indiegames #indiedev #thalamusdigital #thalamus #puppygames

Emre Yaksi's lab found the fish thalamus and its sensory relays to the fish cortex, aka the pallium:

"Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain", Trinh et al. 2025
https://www.biorxiv.org/content/10.1101/2025.09.15.675867v2

#neuroscience #zebrafish #thalamus