SciTech Chronicles. . . . . . . . .April 8th, 2025
#neuroimaging #visual #dorsal #ventral #biomass #bioenergetic #modeling #fermentation #certainty #patterns #independent #clustering #respiration #brain #functions #prefrontal #DNA #on-off #methylation #immune-related
SciTech Chronicles. . . . . . . . .Mar 10th, 2025
#cancer #cardiovascular #saturated #unsaturated #fMRI #prefrontal #frontoparietal #ganglia #fMRI #prefrontal #frontoparietal #ganglia #dopamine #iPSCs #dopaminergic #immunosuppressive #theoretical #voltage #Hydrogen #Oxygen
Excited to share a new paper from the lab:
Encoding of 2D Self-Centered Plans and World-Centered Positions in the Rat Frontal Orienting Field
Activity in the M2 predicts upcoming choices. But what does the activity represent? A gaze-centered plan? A world-centered goal? A specific movement? We asked rats to plan responses to different targets from different start position to find out!
Liujunli Li, Timo Flesch, Ce Ma, Jingjie Li, Yizhou Chen, Hung-Tu Chen and Jeffrey C. Erlich
Journal of Neuroscience 11 September 2024, 44 (37) e0018242024; https://doi.org/10.1523/JNEUROSCI.0018-24.2024
Tweetthread: https://x.com/erlichlab/status/1835716087251406866
#neuroscience #prefrontal #premotor #planning #neuralnetworks
The neural mechanisms of motor planning have been extensively studied in rodents. Preparatory activity in the frontal cortex predicts upcoming choice, but limitations of typical tasks have made it challenging to determine whether the spatial information is in a self-centered direction reference frame or a world-centered position reference frame. Here, we trained male rats to make delayed visually guided orienting movements to six different directions, with four different target positions for each direction, which allowed us to disentangle direction versus position tuning in neural activity. We recorded single unit activity from the rat frontal orienting field (FOF) in the secondary motor cortex, a region involved in planning orienting movements. Population analyses revealed that the FOF encodes two separate 2D maps of space. First, a 2D map of the planned and ongoing movement in a self-centered direction reference frame. Second, a 2D map of the animal’s current position on the port wall in a world-centered reference frame. Thus, preparatory activity in the FOF represents self-centered upcoming movement directions, but FOF neurons multiplex both self- and world-reference frame variables at the level of single neurons. Neural network model comparison supports the view that despite the presence of world-centered representations, the FOF receives the target information as self-centered input and generates self-centered planning signals.
At #Fens2024 tomorrow (Wednesday 26/June) - Check out our poster comparing how representations change in #hippocampus, dorsolateral #striatum, and #prefrontal cortex in rats making decisions as environmental complexity changes.
U. Mugan et al. Poster number 211. In poster session 02: prefrontal decision-making
Some really cool results looking at interactions between decision-making systems!
In-group social bonding stabilizes hierarchical structures in various species. This study shows that social bonding in humans selectively increases information exchange and prefrontal neural synchronization for human leader-follower pairs.
Predicting the effect of micro-stimulation on macaque #prefrontal activity based on spontaneous #CircuitDynamics – exciting new research by Nejatbakhsh et al. (2023) sheds light on neural ensemble interactions.
🌍 https://journals.aps.org/prresearch/abstract/10.1103/PhysRevResearch.5.043211
#Neuroscience #CompNeuro #NonlinearDynamics #BiologicalPhysics
A crucial challenge in targeted manipulation of neural activity is to identify perturbation sites whose stimulation exerts significant effects downstream with high efficacy, a procedure currently achieved by labor-intensive trial and error. It is demonstrated that the effects of electrical microstimulation on neural activity in the prefrontal cortex of alert monkeys can be predicted solely based on the functional connectivity estimated from cortical recordings at rest.
@AllenNeuroLab @cogneurophys yes please a thread!
Beta is where it’s at!
#prefrontal +#thalamus #oscillations in #rat physiology and #opto in an actual item #sequence memory task?
Time to reunien-ize!
Do the thread and then I have questions!
I think I’m due for an #introduction! I’m an MD/PhD student at #uOttawa, doing my PhD in #neuroscience with Jean-Claude Béïque and Richard Naud. My work explores how uncertainty in reward feedback is processed in #prefrontal cortex, mainly in the context of #autism.
To do this, I use #behavior tasks in mice along with simultaneous in vivo two-photon calcium imaging. I also model #learning and #DecisionMaking using #ReinforcementLearning #RL.
Some of my other interests include patch clamp #ephys, post #stroke #synapse remodeling, #serotonin, #psychedelics and #consciousness.
Follow if you want to join me in finding and sharing interesting papers and ideas!
Rauf Atilla Polat
John Vaccaro (johniac)
Jeffrey C. Erlich
Redish Lab
PLOS Biology
Fabrizio Musacchio
kari hoffman
Andrew MacAskill
Sébastien Maillé