michael6d ago

11-Mar-2026
The complete #genome of the #goldenLancehead reveals how genes responsible for #venom #toxins evolved

https://www.eurekalert.org/news-releases/1119646 #science #snakes #ecology #evolution #snakeVenom

The complete genome of the golden lancehead reveals how genes responsible for venom toxins evolved

One of the most complete sequencing projects ever performed on snakes worldwide serves as a reference for all jararaca vipers, which may contribute to new discoveries about toxins and the conservation of the species on Queimada Grande Island in Brazil, where it is critically endangered.

EurekAlert!
Maciej SpiegelDec 8

🎉 New paper published with Prof. Pedro A. Fernandes, Dr. Ana Rita Calixto, and Roberto Pinto from Universidade do Porto!

We used QM/MM to map the catalytic mechanism of Bothrops asper sPLA2 (snake venom toxin) on the NOBA substrate.

The finding: A crucial mixed single-water/assisted water mechanism. This validates NOBA's use, giving researchers vital insights for anti-venom development! 🐍

🔗 https://doi.org/10.1016/j.biochi.2025.12.003

#SnakeVenom #sPLA2 #QM/MM #ComputationalChemistry

AndyMay 3, 2025

#Snakes #SnakeVenom #Venom #BBC #TimFriede #Science #Biology #Immunity #Animals #Poison #Poisonous #Animal #Venomous #Research #antivenom
Quite an amazing story, and Tim Friede could be helping to save thousands of lives for many years to come…

'Unparalleled' snake antivenom made from man bitten 200 times https://www.bbc.com/news/articles/cr5d0l7el36o

'Unparalleled' snake antivenom made from man bitten 200 times

Scientists hope to make a universal antivenom from the extraordinary blood of a man exposed to snake venom for decades.

michaelDec 4, 2024
last year's #CurrentBiology feature on #SnakeVenom now in the open archives:
https://proseandpassion.blogspot.com/2023/12/snake-toxins.html #science #ecology #evolution #snakes #proteinToxins
snake toxins

I have a feeling I did a feature on protein toxins in the early days, maybe 20 years ago, but couldn't find it. So I guess it was about time...

Black Metal Stu🇺🇦🇮🇱Jul 13, 2024
Okay, das #SnakeVenom ist jetzt wohl etwas (#viel) zu #Viel gewesen. Ich kann #Benachrichtigungen zu #Toots nicht mehr auseinander halten. #GuteN8, möge der #Kater morgen ein #gnädiger #sein!
Matt WillemsenMar 1, 2024
Snake venom toxins can be neutralized by a new synthetic antibody
https://www.sciencenews.org/article/snake-venom-toxins-antivenom-synthetic-antibody #medicine #SnakeVenom #neutralize #antibodies #toxinfamilies #alpha—neurotoxins #universal #antivenom
Snake venom toxins can be neutralized by a new synthetic antibody

A lab-made protein protected mice from lethal doses of paralyzing toxins found in a variety of snakes, a new study reports.

Science News
Fauna ThreadsFeb 19, 2024

Meet the Man who Injects Himself with Snake Venom!
https://www.youtube.com/shorts/4Xgqaidc-DU

#wildlife #nature #snakes #snakevenom

🐍💉 Immortality or Insanity? The Man Who Injects Himself with Snake Venom! #shorts

YouTube
michaelJan 5, 2024
4-JAN-2024
Brazilian researchers discover two novel peptides with biotechnological potential in #SnakeVenom
Fragments of hemorrhagic toxins that may help treat high blood pressure were found in the venom of the pit viper Cotiara, which inhabits the South of Brazil, and that of the South American bushmaster, a denizen of tropical rainforests

https://www.eurekalert.org/news-releases/1030292 #science #ecology #snakes #venom
Brazilian researchers discover two novel peptides with biotechnological potential in snake venom

<p>Fragments of hemorrhagic toxins that may help treat high blood pressure were found in the venom of the pit viper Cotiara, which inhabits the South of Brazil, and that of the South American bushmaster, a denizen of tropical rainforests. The molecules might one day be used in drugs with fewer adverse side effects. The researchers were particularly interested in a novel metalloproteinase-derived peptide called Lm-10a, a fragment of a hemorrhagic toxin that inhibits ACE and could potentially be used in a drug to treat blood pressure. </p> <p> </p>

EurekAlert!
🐦‍🔥nemo™🐦‍⬛ 🇺🇦🍉Nov 18, 2023

A #snakevenom-analog #peptide that inhibits #SARSCoV2 and papain-like protease displays #antithrombotic activity in #mice #arterial # thrombosis model, without interfering with #bleeding time

https://thrombosisjournal.biomedcentral.com/articles/10.1186/s12959-022-00436-5

#linktopaper #openaccess

https://thrombosisjournal.biomedcentral.com/counter/pdf/10.1186/s12959-022-00436-5.pdf

A snake venom-analog peptide that inhibits SARS-CoV-2 and papain-like protease displays antithrombotic activity in mice arterial thrombosis model, without interfering with bleeding time - Thrombosis Journal

Background (p-BthTX-I)2 K, a dimeric analog peptide derived from the C-terminal region of phospholipase A2-like bothropstoxin-I (p-BthTX-I), is resistant to plasma proteolysis and inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains with weak cytotoxic effects. Complications of SARS-CoV-2 infection include vascular problems and increased risk of thrombosis; therefore, studies to identify new drugs for treating SARS-CoV-2 infections that also inhibit thrombosis and minimize the risk of bleeding are required. Objectives To determine whether (p-BthTX-I)2 K affects the hemostatic system. Methods Platelet aggregation was induced by collagen, arachidonic acid, and adenosine diphosphate (ADP) in the Chronolog Lumi-aggregometer. The coagulation activity was evaluated by determining activated partial thromboplastin clotting time (aPTT) and prothrombin time (PT) with (p-BthTX-I)2 K (5.0–434.5 µg) or 0.9% NaCl. Arterial thrombosis was induced with a 540 nm laser and 3.5–20 mg kg− 1 Rose Bengal in the carotid artery of male C57BL/6J mice using (p-BthTX-I)2 K. Bleeding time was determined in mouse tails immersed in saline at 37 °C after (p-BthTX-I)2 K (4.0 mg/kg and 8.0 mg/kg) or saline administration. Results (p-BthTX-I)2 K prolonged the aPTT and PT by blocking kallikrein and FXa-like activities. Moreover, (p-BthTX-I)2 K inhibited ADP-, collagen-, and arachidonic acid-induced platelet aggregation in a dose-dependent manner. Further, low concentrations of (p-BthTX-I)2 K extended the time to artery occlusion by the formed thrombus. However, (p-BthTX-I)2 K did not prolong the bleeding time in the mouse model of arterial thrombosis. Conclusion These results demonstrate the antithrombotic activity of the peptide (p-BthTX-I)2 K possibly by kallikrein inhibition, suggesting its strong biotechnological potential.

BioMed Central
Steve Dustcircle 🌹Jun 10, 2023
#COVID19 is caused by a #virus, not #snakevenom; no #snake #venom in #COVID-19 #vaccines, contrary to claim by chiropractor #BryanArdis
https://healthfeedback.org/claimreview/covid-19-caused-virus-not-snake-venom-no-snake-venom-covid-19-vaccines-chiropractor-bryan-ardis/
COVID-19 is caused by a virus, not snake venom; no snake venom in COVID-19 vaccines, contrary to claim by chiropractor Bryan Ardis

Scientific evidence gathered in different laboratories around the world has established that the coronavirus SARS-CoV-2 is the causative agent of COVID-19. Pregnant women are at a higher risk of developing severe COVID-19 and getting COVID-19 increases the risk of pregnancy complications, including miscarriage. Studies so far have shown that COVID-19 vaccines are highly effective at reducing the risk of severe disease and don’t increase the risk of negative pregnancy outcomes. The American College of Obstetricians and Gynecologists recommend that pregnant women get vaccinated against COVID-19.

Health Feedback