Researchers Uncover Potential Pathway To Address Williams-Beuren Syndrome

Williams-Beuren syndrome is a rare, congenital disease in which the main morbidity and mortality comes from obstructions

Is cocoa the cure for too much sitting? New study says yes

Sitting has often been referred to as the new smoking thanks to its negative health benefits. For the first time ever, according to researchers in England, the flavanols in cocoa have been found to block its detrimental effects on blood vessels.

New study confirms far higher risk of blood clots from COVID-19, than from vaccines

A health data study confirms the risk of blood clots is far higher from COVID-19 infection than from vaccination.

Curso virtual sobre medición automática precisa de la presión arterial - versión en español - 2020 (Ext. 2024) | Campus Virtual de Salud Pública (CVSP/OPS)

Global Ambitions for 'MapleStory'—28,000 Concurrent Users Achieved Within One Month of Launch

Nexon's MapleStory Worlds achieved a milestone of 280,000 concurrent users within a month of its global launch, driven by surging international interest and creator-led content such as 'Arterial', which has seen explosive popularity in Taiwan and across streaming platforms.

Artistic Expression by the River featuring Teacher Louise Bourgeois

As a professional artist, the river is my source of inspiration with its steady flow and changing landscape The presence of teacher Louise Bourgeois,his guidance fuels me to convey my emotions through graphic designs and paintings

A snake venom-analog peptide that inhibits SARS-CoV-2 and papain-like protease displays antithrombotic activity in mice arterial thrombosis model, without interfering with bleeding time - Thrombosis Journal

Background (p-BthTX-I)2 K, a dimeric analog peptide derived from the C-terminal region of phospholipase A2-like bothropstoxin-I (p-BthTX-I), is resistant to plasma proteolysis and inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains with weak cytotoxic effects. Complications of SARS-CoV-2 infection include vascular problems and increased risk of thrombosis; therefore, studies to identify new drugs for treating SARS-CoV-2 infections that also inhibit thrombosis and minimize the risk of bleeding are required. Objectives To determine whether (p-BthTX-I)2 K affects the hemostatic system. Methods Platelet aggregation was induced by collagen, arachidonic acid, and adenosine diphosphate (ADP) in the Chronolog Lumi-aggregometer. The coagulation activity was evaluated by determining activated partial thromboplastin clotting time (aPTT) and prothrombin time (PT) with (p-BthTX-I)2 K (5.0–434.5 µg) or 0.9% NaCl. Arterial thrombosis was induced with a 540 nm laser and 3.5–20 mg kg− 1 Rose Bengal in the carotid artery of male C57BL/6J mice using (p-BthTX-I)2 K. Bleeding time was determined in mouse tails immersed in saline at 37 °C after (p-BthTX-I)2 K (4.0 mg/kg and 8.0 mg/kg) or saline administration. Results (p-BthTX-I)2 K prolonged the aPTT and PT by blocking kallikrein and FXa-like activities. Moreover, (p-BthTX-I)2 K inhibited ADP-, collagen-, and arachidonic acid-induced platelet aggregation in a dose-dependent manner. Further, low concentrations of (p-BthTX-I)2 K extended the time to artery occlusion by the formed thrombus. However, (p-BthTX-I)2 K did not prolong the bleeding time in the mouse model of arterial thrombosis. Conclusion These results demonstrate the antithrombotic activity of the peptide (p-BthTX-I)2 K possibly by kallikrein inhibition, suggesting its strong biotechnological potential.