We also saw a shift in TF activity.
Footprinting showed increased NFI binding, especially NFIB, in late-born cohorts. These neurons activate maturation modules faster — possibly guided by chromatin remodeling during neurogenesis.
#NewsMayerlab #TFfootprints #TranscriptionFactors #scATACseq
(5/7)
This shift was mirrored in chromatin accessibility.
scATAC-seq revealed stage-specific enhancer activation, with late-born cells opening distinct regulatory elements — especially in distal regions. A dynamic change in the regulatory landscape.
#NewsMayerlab #Chromatin #Epigenetics #scATACseq
(4/7)
🚨 Application deadline extension! 🚨 Did you miss your chance to apply for #EMBLATAC? You're in luck, because now you have time until next Monday, 22 January, to do so! Apply here: https://s.embl.org/ata24-01
The aim of this course is to enable you to:
🔹Perform complete flow for single cell ATAC-seq experiments
🔹Process and quality control of single cell ATAC-seq data
🔹Visualise the data and call differences between samples
🔹Analyse and interpret the data using existing tools
"NB cells signal to the BM microenvironment, rewiring via macrophage migration inhibitory factor and #midkine signaling specifically #monocytes ..."
#Neuroblastoma paper by Fetahu et al., the latest publication from the Taschner-Mandl lab in Vienna.
Going through this right now - very alike our own work - and talking to a few team members on Wednesday while they visit our center.
#macrophages #scATACseq #scRNAseq #OpenAccess #cancer #immunology
Data available on EGA, behind a DAC.
Christian Mayer
EMBL Events
Gabriele Pollara
Arjan Boltjes
Regenerative Research Fdn/NSCI
Brendan Innes
Haojia Wu