Question to anyone familar with #TransHealthcare #Hematology

Is there a relationship between elevated #WBC (#neutrophils, #lymphocytes, #monocytes) & #Platelets, decreased #RBC, #Hemocrit, #Anemia, #Hgb, #mpv and #HRT for male to female #transgender individuals with no other evidence of blood disease, infection or #cancer?

#CTScans are clean, #BoneMarrowBiopsy clean. Doc wants to repeat however.

Infiltrating #monocytes drive #cardiac #dysfunction in a #cardiomyocyte-restricted mouse model of #SARS-CoV-2 infection, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.01179-24?af=R

These findings establish a mouse #model of SARS-CoV-2 cardiomyocyte infection that recapitulates features of cardiac dysfunctions of COVID-19 and suggests that both viral replication and resultant innate immune responses contribute to cardiac pathology.

13/ 🔗 Read the full paper here: https://www.embopress.org/doi/full/10.1038/s44321-024-00093-3

#Immunology #Research #Platelets #Monocytes #Inflammation #EMBO #Science #MedicalResearch

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

https://insight.jci.org/articles/view/179433

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

#scRNAseq #TCR #carTcells #OpenAccess #science