Nocebo effects are stronger and more persistent than placebo effects in healthy individuals

Der Nocebo-Effekt

Nocebo NoceboDer Nocebo-Effekt: Wenn negative Erwartungen krank machenWas ist der Nocebo-Effekt?Wissenschaftliche HintergründeDer Nocebo-Effekt in der PraxisStrategien zur Vermeidung des Nocebo-EffektsMusikalische Metapher: Der Nocebo-Effekt als unsichtbarer DämonFazit Der Nocebo-Effekt: Wenn negative Erwartungen krank machen In der Psychotherapie und Medizin hört man häufig vom Placebo-Effekt, bei dem positive Erwartungen zu einer Besserung der Symptome führen können, selbst wenn das verabreichte Mittel keinen therapeutischen Wirkstoff enthält. Doch das weniger bekannte Gegenstück, der Nocebo-Effekt, spielt ebenfalls eine wichtige Rolle in der psychologischen und medizinischen Praxis. Der Nocebo-Effekt beschreibt das Phänomen, bei dem negative Erwartungen oder Überzeugungen zu einer Verschlechterung der Symptome führen können. Lassen

Press reports

Press release of the Charité – Universitätsmedizin Berlin

Press reports

Press release of the Charité – Universitätsmedizin Berlin

Sodium bicarbonate induces alkalosis, but improves high-intensity cycling performance only when participants expect a beneficial effect: a placebo and nocebo study - European Journal of Applied Physiology

The study aimed to investigate the effects of sodium bicarbonate (NaHCO3) intake with divergent verbal and visual information on constant load cycling time-to-task failure, conducted within the severe intensity domain. Fifteen recreational cyclists participated in a randomized double-blind, crossover study, ingesting NaHCO3 or placebo (i.e., dextrose), but with divergent information about its likely influence (i.e., likely to induce ergogenic, inert, or harmful effects). Performance was evaluated using constant load cycling time to task failure trial at 115% of peak power output estimated during a ramp incremental exercise test. Data on blood lactate, blood acid–base balance, muscle electrical activity (EMG) through electromyography signal, and the twitch interpolation technique to assess neuromuscular indices were collected. Despite reduced peak force in the isometric maximal voluntary contraction and post-effort peripheral fatigue in all conditions (P < 0.001), neither time to task failure, EMG nor, blood acid–base balance differed between conditions (P > 0.05). Evaluation of effect sizes of all conditions suggested that informing participants that the supplement would be likely to have a positive effect (NaHCO3/Ergogenic: 0.46; 0.15–0.74; Dextrose/Ergogenic: 0.45; 0.04–0.88) resulted in improved performance compared to control. Thus, NaHCO3 ingestion consistently induced alkalosis, indicating that the physiological conditions to improve performance were present. Despite this, NaHCO3 ingestion did not influence performance or indicators of neuromuscular fatigue. In contrast, effect size estimates indicate that participants performed better when informed that they were ingesting an ergogenic supplement. These findings suggest that the apparently ergogenic effect of NaHCO3 may be due, at least in part, to a placebo effect.

The Incredible, Harmful Power of Negative Thinking - Wise & Well - Medium

Real symptoms that shouldn't exist are spawned by the "nocebo effect," a psychosomatic phenomemon rooted in fear and anxiety.