Ion Channel Dysfunction During Critical Illness
https://youtu.be/Ypc9vkf-vCI?si=QmSENBDf89Yhlyd7
This video is from 2013, so perhaps a bit out of date and not news to anyone but me.
Makes me wonder about functional neurological disorder.
I'm also reminded of 'the Ambien effect':
https://youtu.be/KTFicgrVk0w?si=agauhzB5ZzHb7IMR
#brain #neuroscience #polyneuropathy #myopathy #SodiumChannel #CriticalIllness
Pacientes con #COVIDprolongado y fatiga post ejercicio presentan alteración en la estructura muscular: con menor capacidad aeróbica, miopatía grave inducida por #ejercicio infiltración tisular de leucocitos y depósitos de #amiloide en músculos esqueléticos.
Estos cambios empeoran de manera aguda tras el ejercicio
#LongCovid #Exercise #Amyloid #Muscle #Myopathy #MaskUp #CovidIsNotOver
In this longitudinal, case-controlled, cohort design study, authors show that post-exertional malaise is associated with severe exercise-induced myopathy, local and systemic metabolic disturbances and infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID.
New from Spain:
Serum GDF-15 Levels Accurately Differentiate Patients with Primary #MitochondrialMyopathy, Manifesting with Exercise Intolerance and Fatigue, from Patients with #ChronicFatigueSyndrome
Free fulltext:
https://www.mdpi.com/2077-0383/12/6/2435
#Myopathy #DifferentialDiagnoses #MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #MyalgicE #PwME #MEeps
Primary mitochondrial myopathies (PMM) are a clinically and genetically highly heterogeneous group that, in some cases, may manifest exclusively as fatigue and exercise intolerance, with minimal or no signs on examination. On these occasions, the symptoms can be confused with the much more common chronic fatigue syndrome (CFS). Nonetheless, other possibilities must be excluded for the final diagnosis of CFS, with PMM being one of the primary differential diagnoses. For this reason, many patients with CFS undergo extensive studies, including extensive genetic testing and muscle biopsies, to rule out this possibility. This study evaluated the diagnostic performance of growth differentiation factor-15 (GDF-15) as a potential biomarker to distinguish which patient with chronic fatigue has a mitochondrial disorder. We studied 34 adult patients with symptoms of fatigue and exercise intolerance with a definitive diagnosis of PMM (7), CFS (22), or other non-mitochondrial disorders (5). The results indicate that GDF-15 can accurately discriminate between patients with PMM and CFS (AUC = 0.95) and between PMM and patients with fatigue due to other non-mitochondrial disorders (AUC = 0.94). Therefore, GDF-15 emerges as a promising biomarker to select which patients with fatigue should undergo further studies to exclude mitochondrial disease.
I wonder if there are more people on Mastodon who have RYR-1 congenital myopathy. I don't know anybody since it's rare in my country. If anyone sees this and wants to share experiences, I'm interested.
Mathrubhumi English
Rhyothemis
Tom Kindlon
Renata 💻 🎒🦩🐬🌊🥵
Scientific Frontline
Lily 